Cell Growth and Desorption on the Surface of Temperature-sensitive Semi-IPNs Hydrogels Based on Silk Sericin  

作　　者：李学伟 陈莉 

机构地区：[1]State Key Laboratory of Hollow Fiber Membrane Materials and Processes,School of Materials Science and Engineering,TianjinPolytechnic University [2]Chongqing Academy of Metrology and Quality Inspection

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2012年第5期907-910,共4页武汉理工大学学报（材料科学英文版）

摘　　要：Semi-interpenetrating （semi-IPNs） hydrogels containing biocompatible silk sericin （SS） and poly（N-isopropylacrylamide）（PNIPAM） were prepared as novel cellular matrices. Their maximum swelling degree and basic characteristics for biomedical applications such as mouse ？broblasts （L929） cell proliferation and desorption were investigated. The results showed that the incorporation of high hydrophilic SS into PNIPAM hydrogel increased the maximum swelling degree of the semi-IPNs hydrogels, and the adhesion and growth of the L929 on semi-IPNs hydrogels were at least comparable to, or even better than, that on conventional PNIPAM hydrogel. In addition, L929 cells were found to detach from the hydrogels surface naturally by controlling environmental temperature. These results suggest great potential of semi-IPNs hydrogels in tissue engineering.Semi-interpenetrating （semi-IPNs） hydrogels containing biocompatible silk sericin （SS） and poly（N-isopropylacrylamide）（PNIPAM） were prepared as novel cellular matrices. Their maximum swelling degree and basic characteristics for biomedical applications such as mouse ？broblasts （L929） cell proliferation and desorption were investigated. The results showed that the incorporation of high hydrophilic SS into PNIPAM hydrogel increased the maximum swelling degree of the semi-IPNs hydrogels, and the adhesion and growth of the L929 on semi-IPNs hydrogels were at least comparable to, or even better than, that on conventional PNIPAM hydrogel. In addition, L929 cells were found to detach from the hydrogels surface naturally by controlling environmental temperature. These results suggest great potential of semi-IPNs hydrogels in tissue engineering.

关 键 词：semi-interpenetrating hydrogel biocompatible silk sericin N-isopropylacrylamide 

分 类 号：TB39[一般工业技术—材料科学与工程]