妊娠期急性脂肪肝17例临床分析  

Clinical analysis of 17 cases with acute fatty liver of pregnancy

作　　者：龙丽[1] 王玉珏[1] 杨业洲[1] 

机构地区：[1]四川省医学科学院.四川省人民医院妇产科,四川成都610072

出　　处：《实用医院临床杂志》2013年第2期117-119,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨妊娠期急性脂肪肝(acute fatty liver of pregnancy,AFLP)的临床特征、诊治及母儿预后。方法回顾性分析17例AFLP患者的临床资料,总结患者症状、体征、实验室检查及治疗情况。结果 17例AFLP中,孕产妇死亡2例(11.2%),胎儿死亡2例(11.2%)。就诊时患者主要表现为消化道症状,实验室检查提示肝功能异常及凝血机制障碍。治疗措施包括及时终止妊娠、综合治疗、加强监护。结论 AFLP发病凶险,母-胎死亡率高;加强认识、及时诊断及综合治疗可改善其治疗结局。Objective To investigate the clinical characteristics, diagnosis, treatment and maternal-fetal prognosis of acute fat- ty liver of pregnancy （AFLP）. Methods A retrospective analysis was performed in 17 cases with AFLP from January 2003 to Decem- ber 2012 at the department of gynecology and obstetrics in our hospital. Results In 17 cases with AFLP,there were two cases of ma- ternal deaths （ 11.2% ） and two cases of fetal death （ 11.2% ）. The clinical manifestations of the most patients were gastrointestinal symptoms. Laboratory examinations showed abnormal liver function and disturbances of blood coagulation. Treatments included timely termination of pregnancy, comprehensive treatment and intensive care. Conclusions AFLP is a dangerous disease with high rate of mother-fetal death. The understanding of the diseases, timely diagnosis and comprehensive treatment may improve the clinical outcome.

关 键 词：妊娠 急性脂肪肝 

分 类 号：R714.255[医药卫生—妇产科学]