Frank-Starling心脏定律的证明方法探讨  

Discussing the Proof Method of the Frank-Starling Law of the Heart

作　　者：何川[1] 何培芳[2] 

机构地区：[1]四川大学华西医院血液科,四川成都610041 [2]三台县人民医院,四川三台621100

出　　处：《西部医学》2013年第3期348-352,共5页Medical Journal of West China

摘　　要：本文目的在于探讨Frank-Starling心脏定律的科学证明方法。认为证明某一理论的真实性应该包括理论证明(引用科学概念的定义、公理和定律等去判断它的真实性)和实验证明两个方面。理论证明必须首先完成,然后才是设计合理的实验以证明该理论的真实性。理论证明和科学实验的关系是:二者均能否定错误理论,但任何实验结果都不能否定正确的理论证明。众所周知,生命现象有其独特的生物学规律,但它也服从有关的物理学、化学和数学等表达的一般物质的运动规律,因此,心脏作功遵守低级物质的运动形态规律。Frank-Starling定律对心脏搏动作功规律的表达是:心脏收缩释放的能量(作功)是心肌纤维初长度/心室舒张末期容积的函数。显然,该理论对心脏作功规律的表达没有包含收缩时心肌纤维长度的变化情况(例如,没有表达心室收缩末期容积的变化),如此表达心脏作功的规律,不符合物理学中关于作功的定义:Frank-Starling心脏定律不是一个真实的定律。既然理论证明已经十分清楚地显示了Frank-Starling心脏定律是错误的,那么,否定它,只须阐明为什么根据Frank和Starling的实验结果不能推导得出Frank-Star-ling心脏定律理论的理由而不一定再需要做出否定它的实验证明。The method of proving the Frank-Starling Law of the Heart （FSLH） is discussed here in this paper. In order to prove the authenticity of a theory, two things are to be done： 1） deriving theoretic evidences （referring to definitions of scientific concepts, axioms and laws）; 2） collecting experimental evidences. The first, the theoretic evidence should be derived. The second is to design the reasonable experiments to prove the authenticity of the theory. The rela- tionship between the theoretic evidences and the experimental evidences is that both of them can negate a wrong theory, but any experimental results cannot negate the correct theoretical proof. It is well known that even though a life phenomenon is biologically unique, it should also conform to the law of motion of the low-level substances in terms of physics, chemistry and mathematics. And so, the heart working must comply with movement rules of the substance, The FSLH says that the energy of cardiac contraction （cardiac work） is a function of the length of the muscle fiber/the end-diastolic volume. Obviously, the Frank-Starling law＇s treatment of the pattern of the heart working does not include the changes of myocardial fiber length （for example, neglecting the end-systolic volume） during systole, which is not compatible with the basic concept of the ＂work＂ in physics. This shows that the FSLH expressing the fundamental principle of the heart is a failure, and it is not an authentic law. Since the theoretic evidences show very clearly that the FSLH is wrong, the negation of the FSLH does not need to do any experiments to get the evidences, and it only needs to clarify why we cannot deduce from Frank and Starling＇s experimental results getting the theory about the FSLH.

关 键 词：Frank—Starling心脏定律 证明方法 探讨 

分 类 号：R312[医药卫生—基础医学]