还原型谷胱甘肽辅助治疗急性重症胰腺炎前后血浆Ghrelin CRPIL-8和TNF-α浓度的变化  

Effect of glutathione on serum ghrelin,CRP,IL-8 and TNF-α level in patients with severe acute pancreatitis

作　　者：霍本辉[1] 张维[2] 朱涛[3] 闫柏刚[1] 

机构地区：[1]重庆市第三人民医院急诊科,重庆400010 [2]成都医学院第一附属医院呼吸科,四川成都610500 [3]重庆医科大学第二附属医院呼吸科,重庆400010

出　　处：《西部医学》2013年第3期420-423,共4页Medical Journal of West China

摘　　要：目的探讨还原型谷胱甘肽(GSH)辅助治疗急性坏死性胰腺炎前后血浆Ghrelin、CRP、IL-8和TNF-α浓度的变化。方法 100例急性坏死性胰腺炎患者随机分为GSH辅助治疗组(A组,n=50)和一般治疗组(B组,n=50)。于入院时和治疗3天后进行APACHE-Ⅱ评分;并在入院时、治疗1天和3天后,观察血淀粉酶、血脂肪酶、血浆Ghrelin、CRP、IL-8和TNF-α浓度的变化。另外选择门诊体检健康成年人为对照组(C组,n=50)。结果 GSH辅助治疗组和一般治疗组患者APACHE-Ⅱ评分在治疗3天后均明显下降,GSH辅助治疗组下降更明显(均P<0.05)。GSH辅助治疗组和一般治疗组患者血淀粉酶、血脂肪酶、血浆Ghrelin、CRP、IL-8和TNF-α浓度均进行性下降,且GSH辅助治疗组下降更明显(均P<0.05)。结论 GSH对SAP有辅助治疗作用。血浆Ghrelin、CRP、IL-8和TNF-α浓度与SAP病情严重程度相关。Objective To investigate the effect of glutathione （GSH） on serum Ghrelin, CRP, IL-8 and TNF-α level in patients with severe acute pancreatitis. Methods 100 patients with SAP were randomly divided into 2 groups, GSH treatment group and normal treatment group, 50 patients in each. 50 health adults were included as control group. On day 0 and day 3, APACHE-II score was evaluated in SAP patients. On day 0, day 1 and day 3, serum amylase, lipase, Ghrelin, CRP, IL-8 and TNF-α level were documented. Results On day 0, no significant difference on APACHE- lI score was observed between GSH treatment goup and normal treatment group. However, on day 3, a signifcant difference was showed between GLY treatment goup and normal treatment group. On day 0, no significant difference on serum amylase, lipase, Ghrelin, CRP, IL-8 and TNF-α level were identified between GSH treatment goup and normal treatment group. However, on day 1 and day 3, serum amylase, lipase, Ghrelin, CRP, IL-8 and TNF-α level in normal treatment group were higher than in GSH treatment group. Otherwise, serum amylase, lipase, Ghrelin, CRP, IL-8 and TNF-α level in patients with SAP were noticeably higher than in control group. Conclusion Glutathione can be used as an effective drug in SAP. Meanwhile, serum Ghrelin, CRP, IL-8 and TNF-α level were sensitive markers in SAP induced inflammation.

关 键 词：还原型谷胱甘肽(GSH) 急性坏死性胰腺炎 Ghrelin CRP IL-8 TNF-Α 

分 类 号：R657.51[医药卫生—外科学]