糖尿病动物建模前后脂肪细胞因子水平变化  

Adipocytokines Changes in Diabetic Animals Before and After Modeling

作　　者：黄映光[1] 孙若飞[1] 王昆华[1] 龚昆梅[1] 雷毅[1] 郭世奎[1] 赵泉[1] 

机构地区：[1]昆明理工大学附属医院(云南省第一人民医院)普外科,云南昆明650032

出　　处：《昆明理工大学学报（自然科学版）》2013年第1期77-79,共3页Journal of Kunming University of Science and Technology(Natural Science)

基　　金：昆明医科大学研究生创新基金资助;云南省应用基础研究基金资助(2009ZC116M)

摘　　要：实验以雌性滇南小耳猪30头随机分为对照组(n=5)和造模组(n=25),利用高糖高脂饮食辅以小剂量链脲佐菌素诱导建立2型糖尿病滇南小耳猪动物模型,并检测建模前后空腹血清瘦素、脂联素、抵抗素、肿瘤坏死因子-α水平变化并探讨其意义.实验结果显示与对照组相比,造模组小型猪成模2周后血清瘦素、血清抵抗素、血清肿瘤坏死因子-α浓度升高,血清脂联素下降(P<0.05).脂肪细胞因子与2型糖尿病的发生有密切关系.30 female southern Yunnan miniature pigs group （n = 25）. The modeling group enjoys high - are divided into two groups： control group （n = 5 ） and model fat diet supplemented by small dose strepto- zotocin to in- duced type 2 diabetes. The fasting serum leptin, adiponectin, resistin, tumor necrosis factor - level changes be- fore and after modeling are detected, with its significance discussed. The results show： compared with the control group, small pigs in model group have higher serum leptin, resistin and tumor necrosis factor -, while their serum adiponectin decreases （P 〈 0. 05 ）. Adipocytokines is closely related to the occurrence of type 2 diabetes.

关 键 词：糖尿病 瘦素 脂联素 抵抗素 肿瘤坏死因子-Α 

分 类 号：R587.1[医药卫生—内分泌]