药物基因多态性与口服降糖药物效应多样性关系的研究进展  

Progress in drug gene polymorphism and varieties of curative effects of oral antidiabetic drug

作　　者：王丹蕾[1] 于伟[2] 肖江宁[1] 

机构地区：[1]沈阳军区总医院药剂科,沈阳110840 [2]沈阳军区总医院第二干部病房,沈阳110840

出　　处：《实用药物与临床》2013年第2期148-151,共4页Practical Pharmacy and Clinical Remedies

摘　　要：2型糖尿病是一种高发的基础疾病,以药物治疗为主,饮食、运动为辅。在降糖药物的治疗中,由于个体差异,导致疗效及不良反应多样性。药物基因组学是导致这一差异的重要原因,其研究目的是明确遗传因素对药物效应的影响,是近年来一大研究热点。并为临床合理用药提供理论依据,这也势必将成为未来医药学的一个重要发展方向。Type 2 diabetes mellitus is a common epidemic disease, which depends on drug treatment adjuvant with diet and exercise. During the drug treatment, varieties of curative effect and adverse effect resulted of individual difference. While pharmacogenomics is an important cause of individual difference and one of hot points of investigation. Pharmacogenomics will be an important direction of medical and pharmaceutical development as a theoretical foundation for rational use of drug and personalized treatment.

关 键 词：口服降糖药物 基因多态性 药物基因组学 合理用药 个体化治疗 

分 类 号：R587.1[医药卫生—内分泌]