卡介苗多糖核酸注射液对支气管哮喘治疗的临床分析  

Clinical Analysis of BCG-PSN on the Treatment of Bronchial Asthma

作　　者：李春凤[1] 

机构地区：[1]徐州医学院附属医院西院,江苏徐州221002

出　　处：《北华大学学报（自然科学版）》2013年第1期67-70,共4页Journal of Beihua University（Natural Science）

摘　　要：目的以IL-2,IgE和EOS为评价指标,探讨卡介苗多糖核酸注射液(BCG-PSN)对支气管哮喘患者的疗效.方法选择资料健全的哮喘病患者90例,随机分为A,B两组,在其哮喘急性发作期,A组患者采取常规疗法(氨茶碱+β2受体兴奋剂),B组患者在常规疗法的基础上辅以BCG-PSN肌注,4周为1疗程,采取回顾性分析方法对比疗程前后两组患者IL-2,IgE,EOS的变化,总结疗效.结果 1)B组患者治疗后与治疗前相比,EOS计数明显下降,IL-2数值明显升高,IgE阳性例数明显下降,均具有统计学意义(P<0.05);2)与A组患者相比,治疗后EOS计数下降、IL-2数值升高、IgE阳性例数下降更显著,均具有统计学意义(P<0.05).结论 BCG-PSN配合常规疗法可明显改善哮喘患者急性发作期的IL-2,IgE和EOS三个指标,可使患者体内的Th1/Th2平衡向Th1方向转化,Th1细胞占据主导地位,从而有助于平喘,并让患者更加长期地处于平稳状态.Objective To discuss the curative effect of BCG-PSN on patients with bronchial asthma by using IL-2, IgE and EOS as the evaluation indexes. Method 90 Patients were randomly divided into two groups, group A and group B. In the acute stage of asthma, patients in group A were treated with the conventional therapy （aminophylline ＋ 132 receptor agonist ）, and patients in group B patients were treated with BCG-PSN intramuscular injection on the basis of the application of the conventional therapy. One course of the treatment was 4 weeks. A retrospective analysis method was used to compare changes of IL-2, IgE and EOS of patients between the two groups before and after the treatment to summarize the curative effect. Results 1 ）Compared with those of patients in group A before and after the treatment,the EOS counts in group B obviously decreased, IL-2 value significantly elevated and the number of cases with positive IgE was significantly decreased, and the differences were all statistically significant （ P 〈 0.05 ） ; 2 ） Compared with those in group A after the treatment, EOS counts decreased significantly and IL-2 value increased significantly and the number of cases with positive IgE decreased significantly, and the differences were all statistically significant （ P 〈 0.05 ）. Conclusion BCG- PSN therapy combined with routine therapy can significantly improve three indicators of asthma patients, IL-2, IgE and EOS, in the acute exacerbation of asthma, suggesting that the therapy can make the Th1/Th2 balance transform into Th1 direction in the body of patients and Th1 cells occupy the dominant position , which is beneficial to relieving the asthma and making the patients in a steady state for a long term.

关 键 词：哮喘 急性发作期 卡介苗多糖核酸注射液(BCG-PSN) 

分 类 号：R425.6[医药卫生—临床医学]