脑钠肽在呼吸困难鉴别诊断中的价值研究  

The Value Study of Brain Natriuretic Peptide in the Differential Diagnosis of Dyspnea

作　　者：周雨田[1] 马骄[2] 

机构地区：[1]四川省人民医院干部科老年疾病研究所呼吸病房,四川省成都市610072 [2]成都医学院检验医学院

出　　处：《实用心脑肺血管病杂志》2013年第3期50-51,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨脑钠肽(BNP)在呼吸困难鉴别诊断中的价值。方法选择心源性和非心源性呼吸困难患者各80例,在入院时检测血浆BNP、C反应蛋白(CRP)水平及动脉血氧分压(PaO2)和动脉血二氧化碳分压(PaCO2),并进行心脏超声检查。结果心源性呼吸困难组患者的BNP、PaO2水平明显高于非心源性呼吸困难组,PaCO2水平明显低于非心源性呼吸困难组,差异有统计学意义(P<0.05);心源性呼吸困难组患者的左心室舒张末期内经(LVEDD)明显高于非心源性呼吸困难组,左室射血分数(LVEF)、肺动脉压力(MPAP)明显低于非心源性呼吸困难组,差异有统计学意义(P<0.05);两组CRP水平比较,差异无统计学意义(P>0.05)。结论 BNP可作为鉴别心源呼吸困难和非心源性呼吸困难的一个客观指标。Objective To discuss the value of brain natriuretic peptide （BNP） in the diagnosis and differential diagnosis of dyspnea. Methods Selection of cardiogenie and non - cardiogenic dyspnea of the 80 eases of patients, Detection of plasma BNP, C reactive protein at the time of admission （CRP） and arterial oxygen partial pressure level （PaO2） and arterial partial pressure of carbon dioxide （PaCO2）, and cardiac ultrasound. Results Cardiac dyspnea group were BNP, PaO2 levels were significantly higher than that of non cardiac dyspnea group, PaCO2 levels were significantly lower than the non cardiogenic dyspnea group, the difference was statistically significant （P 〈0. 05 ） ; cardiac dyspnea group of patients with LVEDD was significantly higher than that of non cardiogenic dyspnea group, LVEF, MPAP were significantly lower than those in non cardiac dyspnea group, the difference was statistically significant （P 〈 0. 05） ; CRP level two group comparied, there was no significant difference （P 〉 0. 05）. Conclusion BNP can be used as the indicator in the differential diagnosis of dyspnea.

关 键 词：呼吸困难 利钠肽 脑 诊断 鉴别 

分 类 号：R441.8[医药卫生—诊断学]