2型糖尿病人群一级亲属的胰岛素抵抗分析  

Analysis on insulin resistance of first-degree relatives in type 2 diabetes mellitus crowd

作　　者：周强[1] 曾连英[2] 邓英钊[2] 杨静[1] 林桢[1] 陈波[1] 周芸[1] 

机构地区：[1]广州医学院第二附属医院检验科,广州510260 [2]广州医学院医学检验系,2005级广州510182

出　　处：《检验医学与临床》2013年第5期545-547,549,共4页Laboratory Medicine and Clinic

基　　金：广东省医学科研基金资助项目(A2012256)

摘　　要：目的探讨2型糖尿病人群一级亲属(FDR)的胰岛素抵抗指数的变化和临床意义。方法分别测定广州地区2型糖尿病家庭和健康人群家庭成员的体质量指数(BMI)、腰围、臀围、空腹胰岛素(FIN)、空腹血糖(FBG)、血脂的水平,计算胰岛素抵抗指数(IRI)。结果 (1)2型糖尿病与其一级亲属比较,FBG、体脂分布百分比(BF%)差异有统计学意义(P<0.05)。(2)2型糖尿病与健康对照组比较,BF、IR、FBG、三酰甘油(TG)、高密度脂蛋白(HDL)差异有统计学意义(P<0.05)。(3)2型糖尿病其一级亲属与健康对照组比较,BMI、IR、FBG、TG、HDL差异有统计学意义(P<0.05)。(4)IR与BMI、BF、HBCI、TG、HDL有明显相关关系。结论推测2型糖尿病的一级亲属存在胰岛素抵抗高危易感性。肥胖和胰岛素抵抗在向2型糖尿病的发生和发展过程中起了一定作用。Objective To investigate the change of insulin resistance index（HOMA-IR） and its clinical signifi- cance in the first-degree relatives of type 2 diabetes mellitus（T2DM） crowd. Methods To measure the body weight index（BMI） ,waist, hip, fasting insulin（FIN）, fasting blood glucose（FBG） and the blood lipids levels of T2DM fami- lies and the healthy controls in Guangzhou area, and to calculate HOMA-IR. Results （1） There were statistical differences of FBG and body fat（BF） between the T2DM patients and their first-degree relative members（P〈0.05）. （2） There were statistical differences in BF, IR, FBG,TG, and HDL between the T2DM group and the healthy control group（P〈0.05）. （3）There were statistical differences in BMI, IR, FBG, TG and H DL between the first-degree rela- tives of T2DM and the healthy control group. （4） It had significant correlativity between IR with BMI, BF, HBCI,TG and HDL. Conclusion It is conjectured that there is a high-risk susceptibility of IR in the first-degree relatives of T2DM,obese and IR play a certain role in the occurrence and the developing process of T2DM.

关 键 词：2型糖尿病 一级亲属 胰岛素抵抗 肥胖 

分 类 号：R587.1[医药卫生—内分泌]