人参皂苷Rb_1对癫痫大鼠海马神经元的影响  

The influence of Ginseng saponin Rb_1 for epilepsy rat hippocampal neurons

作　　者：吴成举[1] 陈靖[1] 谢鑫[1] 茹东风[1] 

机构地区：[1]辽宁中医药大学,沈阳110032

出　　处：《北方药学》2013年第2期41-42,共2页Journal of North Pharmacy

摘　　要：目的:探讨人参皂苷Rb1对青霉素所致癫痫大鼠作用。方法:将大鼠随机分为正常(A)组、模型(B)组及人参皂苷Rb1(C)组。采用青霉素制作癫痫模型制作方法,观察B组及C组大鼠癫痫发作潜伏期及发作持续时间,并测定各组大鼠海马组织(SOD)、(MDA)含量。结果:C组大鼠发作潜伏期较B组明显延长(P<0.01),发作时间显著缩短(P<0.05)。C组大鼠SOD活性与B组相比显著升高(P<0.01),与A组比较明显降低(P<0.05)。C组MDA含量与B组比较显著降低(P<0.01),与A组比较差异无统计学意义(P>0.05)。结论:人参皂苷Rb1可通过抗氧化机制发挥抗癫痫作用。Objective：To explore ginsenoside Rbl to penicillin cafise epilepsy rat role. Methods： The rats were randomly divided into normal （A） group, model group （B）and ginseng saponin Rb1 （C）group. Using the penicillin production epilepsy model making method, Observe group B and C group of rats epileptic seizure incubation period and the attack last time, And determinate the rat hippocampal tissue （SOD） and （MDA）content.Results： C rats, seizure incubation period was significantly longer than group B （P〈0.01 ）. Onset time was significantly shortened（P〈0.05）. C rats, SOD activity compared with group B significantly increased （P〈0.01）. And group A comparison decreased obviously （P〈0.05）. C group of MDA content and group B is significantly reduced （P〈0.01）. And group A of comparative differences no statistical significance （P〉0.05）. Conclusions：ginsenoside Rbl can through the antioxidant mechanism to play antiepileptic effect.

关 键 词：癫痫 神经元 海马 

分 类 号：R285.5[医药卫生—中药学]