妊娠期糖代谢异常孕妇分娩前血糖水平与新生儿低血糖的关系  

Relationship between blood glucose levels before childbirth of pregnancy sugar metabolism disorders pregnant women and neonatal hypoglycemia

作　　者：方敏[1] 方阅[2] 左文琼[1] 

机构地区：[1]上海市第一人民医院产科,200080 [2]上海市第一人民医院药剂科,200080

出　　处：《中国医药》2013年第3期393-395,共3页China Medicine

摘　　要：目的探讨妊娠期糖代谢异常孕妇分娩前血糖水平与新生儿低血糖的关系。方法收集本院2004年1—12月385例无严重内科并发症、围产期各项检查和记录完整的足月单胎孕妇病历资料并进行回顾性分析。根据血糖检测结果分为对照组（血糖正常，265例）、妊娠期糖尿病（GDM）组（51例）、50g葡萄糖激发试验（GCT）／妊娠期糖耐量（GIGT）异常组（69例）。对比3组孕妇产前5～10min血糖水平及新生儿生后1h血糖水平。结果〈33385例足月新生儿中发生低血糖者20例（5．2％），其中对照组、GCT／GIGT异常组和GDM组发生新生儿低血糖者分别为9例（45．0％）、4例（20．0％）和7例（35．0％），3组间两两比较，差异均无统计学意义（均P〉0．05）。（④对照组、GCT／GIGT异常组和GDM组新生儿生后1h发生低血糖新生儿的血糖均值分别为（2．03±0．87）、（1．85±0．58）、（1．46士0．05）mmol／L，GDM组与对照组的差异有统计学意义（P〈0．05），GCT／GIGT异常组与对照组的差异有统计学意义（P〈0．05），GCT／GIGT异常组与GDM组的差异有统计学意义（P〈0．05）。③对照组、GCT／GIGT组和GDM组孕妇分娩前5～10min血糖水平分别为（5．2±1．2）、（5．3±1．5）和（5．3±1．6）mmol／L，与新生儿生后1h低血糖不相关（r值分别为0．102、0．165和0．244，均P〉0．05）。结论孕妇自身疾病会对新生儿的血糖有一定的影响，应对整个孕期的血糖进行监控，对妊娠期糖代谢异常孕妇分娩新生儿出生后应该进行严密监测。Objective To study the relationship between blood glucose levels before childbirth of pregnancy sugar metabolism disorders pregnant women and neonatal hypoglycemia. Methods All 385 pregnant women with a single baby were recruited from 1st January 2004 to 31st December 2004, without serious physical complications. A retrospective study was performed upon them based on the process of delivery antenatal examination and medical records. It was randomized into three groups according to blood glucose results （normal blood glucose, 265 subjects）, gestational diabetes （GDM） group （51 subjects）, 50 g glucose challenge test （GCT）/gestational impaired glucose tolerance （GIGT） abnormal group （69 subjects）. Compared with hypoglycemia level of newborn in 1st hour and three groups of pregnant women prenatal 5-10 min. Results （1） In the 385 cases of full-term newborns, there were 20 patients （5.2%） with neonatal hypoglycemia. Among them, the control group, GCT/ GIGT abnormal group and GDM group composition of neonatal hypoglycemia occurred more than 9 patients （45.0%）, 4 cases （20.0%） and 7 cases （35.0%） respectively. There was no significant difference between GCT/GIGT abnormal group and the control group （P 〉 0.05）. There was no significant difference between the GDM group and the control group （ P 〉 0.05 ）. There was no significant difference between the GCT/GIGT abnormal group and the GDM group （ P 〉 0.05 ）. （2） The mean low blood glucose of the control group, the GCT/GIGT abnormal group and the GDM group newborns after 1 hour was （2.03 ± 0.87）, （ 1.85 ± 0. 58 ）, （ 1.46 ± 0. 05 ） mmol/L respectively. There was significant difference between the GDM group and the control group （ P 〈 0.05）, and the GCT/GIGT abnormal group and the control group, the difference was statistically significant （ P 〈 0.05）. There was significant difference between the GCT/GIGT abnormal group and the GDM group （P 〈 0.05）. （±） The blood glucose of t

关 键 词：孕妇 婴儿 新生 低血糖症 

分 类 号：R714[医药卫生—妇产科学]