过表达肌浆网Ca^(2+)-ATP酶对慢性心力衰竭犬神经内分泌系统的影响  

Effect of Sarcoplasmic Reticulum Ca^(2+)-ATPase Overexpression on Neuroendocrine System in Chronic Heart Failure Beagles

作　　者：付治卿[1] 李小鹰[1] 鲁晓春[1] 米亚非[1] 周声安[1] 

机构地区：[1]解放军总医院南楼心血管一科,北京市100853

出　　处：《中国康复理论与实践》2013年第2期129-131,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的研究心肌过表达肌浆网Ca2+-ATP酶(SERCA2a)基因对慢性心力衰竭犬神经内分泌系统的影响。方法超声心动图检测SERCA2a基因转导对慢性心力衰竭犬心脏收缩功能的影响,放射免疫法测定血管紧张素Ⅱ与心房利钠肽、内皮素-1、肿瘤坏死因子-α、白介素-6等神经内分泌因子。结果 SERCA2a基因转导后心力衰竭犬的心脏收缩功能得到改善(P<0.05),同时上述神经内分泌因子水平均减低(P<0.05)。结论 SERCA2a过表达能改善心肌收缩功能,阻断神经内分泌系统的恶性循环,可能阻止或逆转心肌重塑。Objective To explore the effect of sarcoplasmic reticulum Ca^2＋ -ATP ase （SERCA2a） overexpression on neuroendocrine sys- tem in chronic heart failure beagles. Methods The cardiac contraction function of chronic heart failure beagles were assessed by echocar- diography before and after SERCA2a gene transduction. Radiation immune method was used to test the serum level of neuroendocrine fac- tors such as Angiotensin II, atrial natriuretic peptide, endothelin-1 and TNF-a, IL-6. Results The cardiac contraction function of chronic heart failure beagles improved greatly （P〈0.05）, and the serum levels of neuroendocrine factors significantly reduced after SERCA2a over- expression （P〈0.05）. Conclusion The vicious circle of neuroendocrine system may be blocked partially by SERCA2a overexpression.

关 键 词：慢性心力衰竭 肌浆网Ca2+-ATP酶 过表达 神经内分泌系统 

分 类 号：R541.6[医药卫生—心血管疾病]