咳喘宁对哮喘豚鼠Eotaxin的调节作用  

Study of the Adjust Effect of Kechuanning on Eotaxin of Asthma Guinea Pigs

作　　者：董晓斐[1] 罗银河[1] 刘红萍[1] 王孟清[1] 

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中医药导报》2013年第2期90-91,共2页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省中医药科研计划课题(2008030);湖南省教育厅科学研究项目(11B09)

摘　　要：目的:观察咳喘宁对哮喘豚鼠Eotaxin的调节作用。方法:将40只豚鼠随机分为:正常对照组,不做任何处理;模型组,用卵清蛋白诱喘;咳喘宁治疗组,使用卵清蛋白诱发哮喘后,用咳喘宁治疗;地塞米松组,使用卵清蛋白诱发哮喘后用地塞米松治疗。采用酶联免疫双抗体夹心(ELISA)法检测各组血中和肺泡灌洗液中Eotaxin的水平。结果:与模型组比较,咳喘宁组血和肺泡灌洗液中的Eotaxin水平明显降低,差异有统计学意义(P<0.05),其作用与地塞米松比较,差异无统计学意义(P﹥0.05)。结论:咳喘宁防治哮喘的作用机制与降低Eotaxin水平有关。Objective： To observe the effect of Kechuanning on adjusting Eotaxin in asthma Guinea pigs. Methods： Forty Guinea pigs were randomized into the control group （CG）,model group（MG）, Kechuanning pretreated group （KPG） and dexam- ethasone pretreated group （DPG）.The animals in MG,KPG and DPG were given egg albumin to establish the model of asthma. The animals in KPG were treated with Kechuanning; and the animals in DPG were treated with dexamethasone. The counts of total Eotaxin in serum and in bronchoalveolar lavage（BALF） were measured according to ELISA.Results： Compared with MG, the contents of Eotaxin in serum and BALF were marked decreased in the guinea pigs of KPG（P〈0.05）, and there was no significant difference between KPG and DPG（P〉0.05）.Conclusion： The mechanism of preventing and curing asthma of Kechuan- ning was related with decreasing the lever of Eotaxin.

关 键 词：哮喘 咳喘宁 地塞米松 EOTAXIN 

分 类 号：R285.5[医药卫生—中药学]