朱砂妊娠用药的实验研究  

Experimental Study on the Use of Cinnabar During Pregnancy

作　　者：陈斌[1] 肖敏[1] 李飞艳[1] 冯传平[1] 李辉[1] 刘杰[1] 

机构地区：[1]湖南中医药高等专科学校,湖南株洲412012

出　　处：《中医药导报》2013年第2期99-100,共2页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:比较孕兔、幼兔、成年兔和新生兔(实验中孕兔所产)血汞含量,探讨不同兔对朱砂中汞的吸收情况。方法:用朱砂定时定量灌胃,用吹气富集-冷原子吸收法测定孕兔、幼兔、成年兔和新生兔血汞含量,并对实验数据进行统计学分析与比较。结果:血汞浓度:孕兔>幼兔>成年兔;新生兔血汞浓度显著高于孕兔给药前的血汞浓度。结论:实验表明朱砂中汞能透过孕兔胎盘屏障进入新生兔体内。鉴于汞的巨大毒性,提出《中国药典》在中药妊娠禁忌药中应增列朱砂。Objectives： To investigate the absorption of the mercury in Cinnabarr by different rabbits, the blood mercury concentrations in pregnant rabbits, young rabbits, adult rabbits and newborn rabbits （the neonatal of the pregnant rabbits used in the experiment） were compared. Methods： The rabbits were given Cinnabar by intragastric administration quantitatively at regular intervals. The blood mercury concentrations in the pregnant rabbits, young rabbits, adult rabbits and newborn rabbits were measured by cold vapour atomic absorption spectrometry, and the experiment data has been analyzed. Results： Blood mercury concentrations were in the series as follows： pregnant rabbits 〉 young rabbits 〉 adult rabbits; The newborn rabbits had significantly higher blood mercury concentrations than that of adult rabbits. Conclusions： Experimental results indicated that the mercury in Cinnabar could through the placental barrier of pregnant rabbits to pass into the fetal rabbit. Considering the severe toxicity of mercury, Cinnabar should be added to the list of the contraindicated traditional Chinese medicines during pregnancy in Chinese Pharmacopoeia.

关 键 词：朱砂 血汞浓度 吹气富集-冷原子吸收法 

分 类 号：R285.5[医药卫生—中药学]