AMPK与心血管疾病  

AMPK and Cardiovascular Disease

作　　者：苏岩[1] 季宇彬[1] 郭鹏[2] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心,黑龙江哈尔滨150076 [2]北京协和医学院中国医学科学院药用植物研究所,北京100193

出　　处：《黑龙江医药》2013年第1期20-24,共5页Heilongjiang Medicine journal

基　　金：国家自然科学基金(81001437);北京市自然科学基金(7102111)

摘　　要：AMPK(AMP-activated protein kinase,腺苷酸活化蛋白激酶)是一种异源三聚体酶,存在于多种组织,如肝脏、骨骼肌、心肌、脑等。AMPK对调节体内能量平衡起到至关重要的作用,被称为"细胞能量感受器"。当机体受到生理或病理刺激导致能量消耗时,AMPK被激活,关闭合成代谢途径,抑制ATP消耗;开启分解代谢途径,维持细胞内ATP总水平。研究表明,AMPK的激活能够通过一些生理和药理作用因子,对心血管疾病产生积极的调节。因此,进一步深入对AMPK调节作用的研究,将为治疗心血管疾病提供新的治疗靶点。The AMP- activated protein kinase（AMPK） is a heterotrimeric protein serine/threonine（Ser/Thr） kinase u- biquitously expressed in mammalian tissues, such as liver, skeletal muscle, myocardium and brain. AMPK acts as a sensor of cellular and whole - body energy status, plays a crucial role in censoring energy status in eukaryotie cells. Physiological or pathological stimuli that deplete cellular energy levels result in an increased AMP/ATP ratio that, in turn, activates AMPK. The activation of AMPK coordinating catabolism and anabolism that maintain cellular ATP levels. Furthermore, there is increasing evidence that activation of AMPK can mediate a number of physiological and pharmacological factors that exert ben- efieial effects on metabolism and the vaseulature. Therefore, a greater understanding of specific AMPK signalling pathways and their regulation will be crucial for vascular disease treatment in the future.

关 键 词：AMPK(腺苷酸活化蛋白激酶) 心血管疾病 治疗靶点 能量代谢 

分 类 号：R54[医药卫生—心血管疾病]