亚临床甲状腺功能减退与颈动脉内膜中层厚度关系的Meta分析  

Associations between Subclinical Hypothyroidism and Carotid Intima Media Thickness:A Meta Analysis

作　　者：王海龙[1] 张娜[1] 张文良[1] 时景璞[1] 

机构地区：[1]中国医科大学附属第一医院临床流行病学与循证医学教研室,辽宁省沈阳市110001

出　　处：《中国全科医学》2013年第5期479-482,共4页Chinese General Practice

摘　　要：目的综合评价亚临床甲状腺功能减退(SCH)与颈动脉内膜中层厚度(C-IMT)的关系。方法检索2001年1月—2011年8月发表的有关SCH与C-IMT关系的文献及其参考文献,提取数据并计算加权均数差(WMD)及95%CI,采用Begg's检验法评价发表偏倚。应用Stata 11.0软件对SCH与C-IMT的关系进行Meta分析。结果共纳入9篇文献。(1)合并结果显示,SCH组与正常对照组的C-IMT差异有统计学意义〔WMD=0.05,95%CI(0.02,0.07)〕。(2)亚组分析显示,平均年龄<60岁的SCH组与正常对照组比较C-IMT间差异有统计学意义(P<0.05);医院来源的SCH组与正常对照组比较C-IMT间差异有统计学意义(P<0.05);无论TSH水平<10 mU/L还是TSH水平≥10 mU/L,SCH患者与正常对照者C-IMT间差异均有统计学意义(P<0.05),且TSH水平≥10mU/L组合并WMD较TSH水平<10 mU/L组合并WMD大。结论 SCH与C-IMT有一定相关性,SCH可能导致颈动脉内膜增厚。Objective To explore the associations between subclinical hypothyroidism （SCH） and carotid intima- media thickness （C - IMT）. Methods The literatures on associations of SCH and C - IMT published between January 2001 and August 2011were retrieved in large databases. The data were extracted and the weighted mean difference （WMD） and 95% CI were calculated. Publication bias was assessed by Begg＇s test. Stata 11.0 was used to perform meta analysis on the associa- tions between SCH and C - IMT. Results A total of nine articles were included in the study. Analysis results showed that C - IMT of SCH patients and normal controls was significantly different [ WMD = 0.05, 95 % CI （0. 02, 0. 07） ]. Subgroup analysis showed that C - IMT were significantly different between SCH patients and normal controls in mean age 〈 60 years old group, and between hospital based SCH patients and normal controls （P 〈 0. 05）. The differences were significant in both TSH level 〈 10 mU/L and TSH level ≥ 10 mU/L groups, and the combined value of WMD in TSH level ≥10 mU/L group was greater than that in TSH level 〈 10 mU/L group. Conclusion SCH was associated with C - IMT.

关 键 词：亚临床甲状腺功能减退 颈动脉疾病 颈动脉内膜中层厚度 META分析 

分 类 号：R581.2[医药卫生—内分泌] R543.51[医药卫生—内科学]