润燥止痒胶囊联合非索非那定治疗老年性皮肤瘙痒症68例  

Clinical observation of Runzaozhiyang capsule combined with Fexofenadine in treating senile skin pruritus

作　　者：王永强[1] 刘春梅[1] 张红岩[1] 赵建伟[1] 赵桂香[1] 谢文杰[2] 

机构地区：[1]河北大学附属医院,河北保定071000 [2]保定市第一中心医院,河北保定071000

出　　处：《医学研究与教育》2013年第1期54-56,共3页Medical Research and Education

摘　　要：目的研究润燥止痒胶囊联合非索非那定口服治疗老年性皮肤瘙痒症的疗效。方法将128例患者随机分为两组,治疗组68例给予润燥止痒胶囊口服,4粒/次,3次/日,联合非索非那定口服,60毫克/次,2次/日;对照组60例,仅给予非索非那定口服,60毫克/次,2次/日。两组均治疗2周,4周判定疗效。结果治疗组和对照组治疗的有效率分别为92.65%和78.33%,两者差异有统计学意义(χ2=5.404,P<0.05);两组中的患者在瘙痒程度、发生频率、持续时间、瘙痒面积等几方面差异均有统计学意义(P<0.05)。结论润燥止痒胶囊联合非索非那定治疗老年瘙痒症具有较好疗效,不良反应发生率低。Objective To observe the curative effects of Runzaozhiyang capsule combined with Fexofenadine oral in the treatment of senile skin pruritus. Methods 128 patients were randomly divided into two groups, 68 cases in treatment group treated with Runzaozhiyang Capsule oral, 4 tablets/time, 3 times/day, combined with Fexofenadine oral, 60rag/time, 2 times/day; 60 cases of the control group, only received fexofenadine oral, 60mg/time, 2 times/day. Two groups were treated for 2 weeks, 4 weeks to judge the curative effects. Results The treatment effectiveness of the treatment group and the control group were respectively 92.65% and 78.33%, there was significant difference（z2=5.404, P〈0.05）; The pruritus severity, frequency, duration, pruritus area also had significant difference（P〈0.05）. Conclusion Runzaozhiyang capsule combined with Fexofenadine in the patients of the two groups have good curative effects and low incidence of adverse reactions in the treatment of senile pruritus.

关 键 词：润燥止痒胶囊 非索非那定 老年性皮肤瘙痒症 

分 类 号：R758.3[医药卫生—皮肤病学与性病学]