光响应温敏嵌段共聚物的合成及其低临界溶解温度的后调控研究  

Synthesis of Thermo-sensitive Block Copolymer and the Post-control of Its Lower Critical Solution Temperature with Light Triggering

作　　者：林昕[1] 赖金平[1] 赵一兵[1] 

机构地区：[1]厦门大学化学化工学院,福建厦门361005

出　　处：《厦门大学学报（自然科学版）》2013年第2期221-225,共5页Journal of Xiamen University：Natural Science

基　　金：国家自然科学基金项目(20835005;21075101);厦门市科技计划项目(3502Z20113006)

摘　　要：利用原子转移自由基聚合(ATRP),以端基修饰2-溴-2-甲基丙酰基的聚乙二醇(PEG-Br)引发温敏单体N-异丙基丙烯酰胺(NIPAM)和光活性单体邻硝基苄基丙烯酸酯(NBAE)共聚,制备得到具有光响应特性的温敏嵌段共聚物.动态光散射实验和紫外-可见吸收光谱表明,该聚合物的低临界溶解温度(LCST)可以通过紫外光照(λ≥310nm)进行后调控,在10mmol/L pH 7.4磷酸缓冲液(PBS)中,可获得聚合物LCST达约26℃的调控幅度.该光响应温敏嵌段共聚物具有良好的水溶性,LCST可调控范围广,产物稳定,有望应用于建立新型药物控制释放系统.Thermo-sensitive block copolymer was synthesized by using atom transfer radical polymerization （ATRP） with PEG-Br,N-isopropyl acrylamide （NIPAM） and o-nitrobenzyl acrylate （NBAE） as macroinitiator,temperature sensitive monomer and light responsive monomer,respectively.The synthesized copolymer was characterized by dynamic light scattering and UV-VIS absorption.The results showed that lower critical solution temperature （LCST） of the polymer can be finely tuned within a relative broad range （～26 ℃） in 10 mmol/L,pH 74 phosphate buffered saline by UV irradiation （λ ≥ 310 nm）.This novel light responsive and thermo-sensitive block copolymer demonstrated wide LCST tunability,good aqueous solubility and stability,should have great potential in applications such as controlled drug delivery.

关 键 词：后调控 光响应 温敏嵌段共聚物 低临界溶解温度 

分 类 号：O633[理学—高分子化学]