乙型肝炎病毒核心IgM抗体定量在诊治中的意义  

Significance of HBV core IgM quantification in diagnosis and treatment of hepatitis B

作　　者：吴坚敏[1] 黄其俊[1] 严爱芬[1] 

机构地区：[1]浙江省余姚市人民医院,浙江余姚315400

出　　处：《中国卫生检验杂志》2013年第2期411-412,415,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨乙型肝炎病毒核心IgM抗体定量检测在乙型肝炎诊治中的意义。方法:采用化学发光免疫分析对822例HBsAg阳性血清进行HBc-IgM定量检测与部分随访,并与丙氨酸氨基转移酶(ALT)、乙型肝炎核酸(HBV DNA)、乙肝二对半分析比较。结果:同样是大三阳模式或小三阳模式,HBc-IgM阳性患者的ALT异常率为61.7%、53.1%,HBV DNA阳性率为99.6%、94.9%,明显高于HBc-IgM阴性患者的。结论:HBc-IgM与ALT、HBV DNA密切相关,当抗病毒治疗有效时能迅速下降甚至转阴,HBc-IgM的定量检测对明确乙型肝炎患者的感染病程、病情、预后评估具有临床意义。Objective：To explore the significance of quantitative assay of hepatitis B virus core IgM antibody in diagnosis and treatment of Hepatitis B. Methods ： HBe - IgM in serum of 822 cases with positive HBsAg was quanti- tatively detected and partly followed up by using chemiluminescence immune assay, and analysis and comparison were made with alanine aminotransferase （ ALT）, hepatitis B nucleic acid （HBV DNA） and HBV Markers. Re- sults ： ALT abnormal rates in the HBc - IgM positive group were 61.7% and 53.1% , HBV DNA positive rates were 99.6% and 94.9%, obviously higher than those of the HBc - IgM negative group with the same HBV Markers pat- tern. Conclusion ： HBc - IgM is closely associated with ALT and HBV DNA. Effective antiviral treatment can cause lgM to decrease rapidly or become negative, the quantitative assay of HBe - IgM has clinical significance for clearing infection course of disease, illness condition and prognosis evaluation of the Hepatitis B patients.

关 键 词：乙型肝炎病毒核心IgM抗体 丙氨酸氨基转移酶 

分 类 号：R512.62[医药卫生—内科学]