阵发性心房颤动进展为持续性心房颤动前的血浆醛固酮水平  

The level of plasma aldosterone in patients with paroxysmal atrial fibrillation before persistent atrial fibrillation occurring

作　　者：黄婷[1] 赵庆彦[1] 于胜波[1] 杨波[1] 

机构地区：[1]武汉大学人民医院心血管内科,湖北武汉430060

出　　处：《中国心脏起搏与心电生理杂志》2013年第1期38-39,共2页Chinese Journal of Cardiac Pacing and Electrophysiology

摘　　要：目的测定阵发性心房颤动(简称房颤)进展为持续性房颤前血浆醛固酮水平变化。方法选取本院心内科阵发性房颤患者91例,所有患者入选后行心脏超声、长程心电图和血生化检查,测定空腹清晨窦性心律时血清醛固酮浓度。结果随访18±6个月,86例完成随访,其中15例进展为持续性房颤。持续性房颤组在年龄、高血压、冠心病和心功能不全和醛固酮水平(302.7±78.3 pg/ml vs 234.3±69.6 pg/ml,P<0.01)与阵发性房颤组有差异。多因素回归分析显示年龄、左房内径、左室射血分数和醛固酮是阵发性房颤进展为持续性房颤的独立危险因素。结论阵发性房颤患者进展为持续性房颤前血清醛固酮水平升高。Objective To investigate changes of serum aldosterone levels in paroxysmal atrial fibrillation （PAF） progressing to persistent atrial fibrillation. Method Ninety-one patients with PAF were prospectively selected ＇after which they underwent a series of tests like echocardiography, a 24-hour Holter monitoring and blood biochemical tests at the time of entry. Radio y was used to determine the serum aldosterone level. Result After follow up of l 8±6 months, the condition of 15 patients progressed to persistent atrial fibrillation. The levels of aldosterone in patients with persistent atrial fibrillation were significantly higher than that in PAF patients（302.7±78.3 pg/ml vs 234.±69.6 pg/ml ,P〈0.01 ）. Patients with persistent atrial fibrillation had a significantly larger probability of having one of the risk factors like hypertension, age, coronary heart diseases, heart failure and increased levels of plasma aldosterone than in the PAF patients. Multivariate logistic regression analysis identified age,hypertension, heart failure, left ventricular ejection fraction and levels of plasma aldosterone as independent risk factors for the progression of PAF to persistent atrial fibrillation. Conclusions The levels of aldosterone in patients with persistent atrial fibrillation are significantly higher than that of PAF patients.

关 键 词：心血管病学 醛固酮 心房颤动 阵发性心房颤动 持续性心房颤动 预测 

分 类 号：R541.75[医药卫生—心血管疾病]