MRI荧光双模态分子影像探针研究进展  

Progress of MRI-optical dual-modality molecular imaging probes

作　　者：周明[1] 刘治国[1] 叶秋稷[1] 曾文彬[1] 

机构地区：[1]中南大学药学院和分子影像研究中心,长沙430013

出　　处：《磁共振成像》2013年第1期71-75,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:30900377;81271634);湖南省自然科学基金(编号:12JJ012)

摘　　要：非入侵性显像技术对于研究生物体真实生理状态和机制具有十分重要的意义。由于每种显像技术都有其自身的局限性,难以同时满足定量、实时以及分辨率和灵敏度等的要求,因而多模态显像技术成为当前非入侵分子影像领域发展的主流。MRI-荧光显像技术的融合由于综合了结构分辨率和检测灵敏度的优点引起了人们极大关注。作者主要对当前MRI-荧光双模态分子探针的发展现状进行综述。Noninvasive molecular imaging techniques are important for understanding the actual conditions and mechanisms of biological systems. More interests in the de velopment of noninvasive molecular imaging have shifted toward multimodality imaging, for no single imaging modality possesses all ideal traits of being quantitative and longitudinal, and provides both high resolution and sensitivity. The combination of non-ionizing MRI and fluorescent techniques has received more attention because of their highly complementary capabilities for anatomical resolution and detection sensitivity. Herein, we report the latest progress in the field of MRI-fluorescent dual modality imaging.

关 键 词：磁共振成像 荧光 分子探针 诊断显像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R318[医药卫生—诊断学]