急性一氧化碳中毒后迟发性脑病患者事件相关电位检测的临床价值  

Clinical value of event related potential test for delayed encephalopathy after acute carbon monoxide poisoning patients

作　　者：史玫[1] 赵建民[2] 吴强[2] 衣学伟[2] 杜云红[3] 顾家鹏 王传升[3] 

机构地区：[1]新乡市中心医院功能检查科,河南新乡453000 [2]新乡市中心医院神经内科,河南新乡453000 [3]新乡医学院第二附属医院精神科,河南新乡453002

出　　处：《新乡医学院学报》2013年第2期128-130,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨急性一氧化碳中毒后迟发性脑病(DEACMP)患者的认知功能状况,为其临床寻找客观的实验室依据。方法将66例急性一氧化碳中毒患者根据病情进展是否发生DEACMP划分为DEACMP组和非DEACMP组。分别对2组患者进行了事件相关电位(ERP)检测和长谷川简易智能量表(HDS)评分,并将结果进行比较。结果与非DEACMP组比较,DEACMP组ERP测定中N2、P3波潜伏期延长,P3波幅降低,差异有统计学意义(P<0.01);DEACMP组HDS评分较非DEACMP组明显降低,差异有统计学意义(P<0.01)。DEACMP组ERP成分中P3波潜伏期与HDS评分呈负相关(r=-0.45,P<0.01),而P3波幅与其呈正相关(r=0.44,P<0.01)。结论 DEACMP患者存在明显的认知功能障碍,ERP可作为评价DEACMP患者认知功能的实验室指标应用于临床。Objective To explore the cognition of patients with delayed encephalopathy after acute carbon monoxide poisoning （DEACMP） , in order to find the laboratory indexes for the clinic. Methods A total of 66 patients with acute carbon monoxide poisoning were divided into DEACMP group and non-DEACMP group according to whether making advancement of delayed encephalopathy or not. Event-related potential （ERP） and Hasegawa dementia scale （HDS） were used for the two groups and the results were compared between them. Results Compared with the non-DEACMP group,the latency of N2 and P3 of ERP were significantly longer and the amplitude of P3 was significantly lower in the DEACMP group （ P 〈 0.01 ）. The scores of HDS in the DEACMP group were significantly lower than those in the non-DEACMP group（ P 〈 0.01 ）. Correlation a- na｜ysis showed that there was a remarkable negative correlation with the scores of HDS and latency of P3 of ERP in the DEAC- MP group（ r = - 0. 45 ,P 〈 0.01 ）, and a significant positive correlation with the amplitude of 173 （ r = 0.44 ,P 〈 0.01 ） respec- tively. Conclusion DEACMP patients have the cognitive dysfunction obviously. ERP test can be used as clinical indexes of cognition for patients with DEACMP.

关 键 词：认知 急性一氧化碳中毒 迟发性脑病 事件相关电位 

分 类 号：R595.1[医药卫生—内科学]