动脉粥样硬化基因治疗的研究进展  

Research Progress of Gene Therapy for Atherosclerosis

作　　者：翟慧[1] 杨毅宁[1] 

机构地区：[1]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054

出　　处：《医学综述》2013年第4期577-580,共4页Medical Recapitulate

基　　金：国家自然科学基金(81160042)

摘　　要：心血管疾病是危害人类健康的主要疾病,动脉粥样硬化(AS)是心血管疾病的重要病理基础,是防治心血管病的根本措施。AS是以脂质代谢紊乱,血管内皮细胞受损,炎性细胞浸润,斑块破裂和血栓形成为特征的慢性病理过程。基因治疗是目前探索治疗AS的新途径,但还主要处于动物实验阶段。如何有效地运用基因治疗AS已成为近年来研究的热点,该文就AS基因治疗的基本内容和进展予以综述。Cardiovascular disease is the major disease threatening human health. Atherosclemsis（AS） is the important pathological basis of cardiovascular disease and the fundamental measures to prevent cardiovas- cular disease. AS is a chronic pathological process featured with lipid metabolism disorder, vascular endotheli- al eelldamage,inflammatory cell infiltration, plaque rapture and thrombosis. Gene therapy is currently explo- ring new ways of treatment for AS, but still largely in the stage of animal experiments. How to use gene thera- py to treat AS effectively has become a hot research spot in recent years. Here is to make a review on the con- tent and progress of gene therapy for AS.

关 键 词：动脉粥样硬化 基因治疗 靶点 

分 类 号：R543.5[医药卫生—心血管疾病]