药疹患者体内体液免疫指标的临床观察  

Research on the changes of several humoral immune index in drug eruption patients

作　　者：朱启星[1,2] 肖凤丽[1] 周伏圣[1] 张家祥[2] 沈彤[1] 

机构地区：[1]安徽医科大学第一附属医院皮肤病研究所,合肥230022 [2]安徽医科大学公共卫生学院劳动卫生与环境卫生系,合肥230032

出　　处：《安徽医科大学学报》2013年第4期426-427,共2页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:38072147)

摘　　要：目的探索体液免疫在药疹发生发展过程中的作用,探讨药疹的发病机制。方法收集25例药疹患者血清及相关临床资料,并按一定条件匹配25例正常对照者;对药疹患者及正常对照者部分体液免疫相关血清指标进行分析,比较两组之间各个指标的差异。结果药疹患者与正常对照者免疫球蛋白IgG、IgM、IgA比较存在明显差异(P<0.05),补体C3、C反应蛋白及循环免疫复合物的差异也有显著性(P<0.05)。结论体液免疫在药疹发生发展过程中可能起到重要的作用,并且药疹患者病程中可能存在补体活化现象。Objective To explore the development of the humoral immune in drug eruption, and to investigate the pathogenesis of drug eruption. Methods We collected the serum and clinical data of 25 patients and 25 cases of normal controls according to certain conditions with patients. The differences in each index between drug eruption patients and normal control groups were analyzed. Results There were obvious differences between two groups in immunoglobulin IgG, IgM, IgA, C3, C-reactive protein and circulating immune complexes, and the difference was statistically significant（P 〈 0. 05）. Conclusion Humoral immunity may play an important role in the pathogenesis of drug eruption. The complement-activation may be in drug eruption patients.

关 键 词：药疹 体液免疫 补体 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]