雷诺嗪对豚鼠离体心肌缺血-再灌注损伤心功能的保护作用  

The protection effect of Ranolazine in vitro myocardial ischemia-reperfusion injury heart function in guinea pig

作　　者：贾洪君[1] 王国涛[1] 张文杰[2] 

机构地区：[1]大庆市第四医院心内科,黑龙江省163712 [2]吉林大学基础医学院生理教研室

出　　处：《中国心血管病研究》2013年第3期220-222,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨雷诺嗪对豚鼠离体缺血一再灌注模型的心功能保护及其作用机制。方法通过离体Langendom模型灌流方法，观察雷诺嗪对血流动力学改变和心肌钙离子含量变化的作用。结果雷诺嗪可增加缺血再灌注心肌LVDP、＋dp／dtmax和-dp／dtmax水平，减少再灌注末心肌组织Ca2＋含量；R1、R2与I／R组相比较，P〈0．05，P〈0．05，P〈0．05，R1与R2组比较P〈0．05。结论雷诺嗪可改善心脏收缩、舒张功能，防止心肌细胞钙超载，并且呈剂量依赖性。Objective To investigate the protection effect of Ranolazine on myocardial ischemia-reperfusion injury heart function in guinea pig and its mechanism. Methods By in vitro model of Langendorff perfusion method, observation of ranolazine on hemodynamics, myocardial calcium content change. Results Ranolazine may increase myocardial ischemia reperfusion, LVDP and dp/dtmax levels, reduce the content of Ca2＋ in soil. Compared to R1, R2 and I/R groups, P〈0.05, P〈0.05, P〈0.05, R1 and R2 groups （P〈0.05）. Conclusion Ranolazine improves systolic, diastolic function, prevent myocardial cell calcium overload, and in a dose-dependent manner.

关 键 词：雷诺嗪 缺血-再灌注模型 心功能 

分 类 号：Q95-33[生物学—动物学] R542.2[医药卫生—心血管疾病]