2型糖尿病合并感染时免疫分子的变化  

Observations on the Changes of Immunoglobulins and IgG Subclasses in Cases of NODDM Complicated with Infections

作　　者：潘继豹[1] 卢学勉[1] 叶家鹤[1] 林峰[1] 

机构地区：[1]浙江省瑞安市人民医院,325200

出　　处：《浙江临床医学》2000年第5期300-301,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 探讨2型糖尿病患者合并感染时免疫球蛋白、IgG亚类及补体的变化关系。方法 用速率散射免疫比浊法 ,测定56例患者的IgG、IgA、IgM、IgG亚类 ,C3、C4,IgG亚类试剂为高亲和力的多克隆抗体。 结果 非感染组较对照组IgG显著下降 (p<0.01) ,并以IgG1、IgG2下降为主 (p<0.01 ,p<0.05) ;合并感染组较对照组IgA、C3、C4显著升高 (p<0.01 ,p<0.05 ,p<0.05) ,而IgM无显著变化 (p>0.05)。 结论 NIDDM患者的免疫球蛋白存在改变或失衡 。Objective To examine the variations of serum immunoglobulin and IgG subclasses in DM2 patients with infections. Methods Detections were made by using rate immuno-nephelometry and high affinity polycolonal antibodies of the IgG subclasses. Results Of 56 DM2 cases detected, IgG level in non-infection group decreased significantly compared with that in control group ( P<0.01), and most significantly decreased were observed in IgG1 and IgG2 (P<0.01, P<0.05 , respectively ). However, IgA C3 and C4 were significantly increased in the infection group (P<0.01,P<0.05, P<0.05 ), but IgM revealed no significant changes. Conclusion DM2 cases had severe immunoglobulin changes, which could be the causes of being liable to suffer from infections.

关 键 词：Ⅱ型糖尿病 免疫球蛋白 IgG亚类型 感染 并发症 

分 类 号：R587.2[医药卫生—内分泌]