细胞膜电位对非离子通道膜蛋白功能的调节  

Modulation of non-ion channel proteins by membrane potential

作　　者：陈兴娟[1] 张熙东[1] 张璇[1] 徐佳曦[1] 张海林[1] 

机构地区：[1]河北医科大学基础医学院药理研究室,石家庄050017

出　　处：《中南大学学报（医学版）》2013年第2期216-220,共5页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(31270882)~~

摘　　要：细胞膜内外两侧离子种类的不均匀分布以及不同离子顺各自电化学梯度扩散形成了细胞膜电位(transmembrane potential)。膜电位对许多功能性的膜蛋白具有调节作用例如:离子通道(ion channels)、转运体(transporters)、钠钾泵(pumps)以及一些酶类(enzymes)等。膜电位的改变对细胞膜功能蛋白的调节是电刺激信号转成细胞内信号转导的关键,电压门控离子通道的研究比较广泛,也是大家所熟悉的,而膜电位对细胞膜非离子通道功能蛋白也具有重要的调节作用。Objective： The different concentration of specific ion species and the electrodiffusion of the ions down their electrochemical gradient generate transmembrane potential. The regulation of membrane potential for the function of numerous membrane proteins such as ion channels, transporters, pumps and enzymes plays primary role in the conversion of extracellular electric stimulation into a sequence of intracellular biochemical signals. Some ion channels regulated by membrane potential are well known, and the membrane non-ion channels protein is also modulated physiologically by membrane potential.

关 键 词：细胞膜电位 电压感受蛋白 门控电流 信号转导 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]