Decarboxylative Alkylation of β-Keto Acids with Isochromans under Oxidative Conditions  

作　　者：Yan Chen Shi-Kai Tian 

机构地区：[1]Joint Laboratory of Green Synthetic Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China [2]Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2013年第1期37-39,共3页中国化学（英文版）

基　　金：Acknowledgement We are grateful for the financial support from the National Natural Science Foundation of China （21232007 and 21172206）, the National Basic Research Program of China （973 Program 2010CB833300）, and the Program for Changjiang Scholars and Innovative Research Team in University （IRT1189）.

摘　　要：An unprecedented decarboxylative alkylation reaction of fl-keto acids with isochromans has been developed under oxidative conditions. A range of β-keto acids smoothly undergo decarboxylative alkylation with isochromans in the presence of 2,2,6,6-tetramethylpiperdine-1-oxoammonium hexafluorophosphate to give structurally diverse 1-acylmethylisochromans in moderate to excellent yields with extremely high regioselectivity.An unprecedented decarboxylative alkylation reaction of fl-keto acids with isochromans has been developed under oxidative conditions. A range of β-keto acids smoothly undergo decarboxylative alkylation with isochromans in the presence of 2,2,6,6-tetramethylpiperdine-1-oxoammonium hexafluorophosphate to give structurally diverse 1-acylmethylisochromans in moderate to excellent yields with extremely high regioselectivity.

关 键 词：β-keto acids isochromans 2 2 6 6-tetramethylpiperdine-l-oxoammonium salts DECARBOXYLATION al-kylation 

分 类 号：TQ241.1[化学工程—有机化工] TQ531.6