First Total Synthesis of the Proposed Structures of Orisuaveolines A and B  

作　　者：Jie Zhang Shijun Da Xiaolin Feng Xiaoyi Chen Jianhui Jiang Ying Li 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China

出　　处：《Chinese Journal of Chemistry》2013年第1期123-126,共4页中国化学（英文版）

基　　金：Acknowledgement We are grateful to the financial support of the Na- tional Natural Science Foundation of China （Nos. 21072084, 21272099） and Fundamental Research Founds for the Central Universities （No. lzujbky-2010- 107）. We also thank Prof. Quanxiang Wu of Lanzhou University for helpful discussions.

摘　　要：First total synthesis of the proposed structures of β-indoloquinazoline alkaloids orisuaveolines A and B is re- ported. The key steps of the synthesis included a Pictet-Spengler reaction to build a six-member lactam which fur- ther transformed into target molecular by a one-pot condensation. This synthesis provided an access to the proposed structures of orisuaveolines A and B in a short and convenient manner from inexpensive, commercially available starting materials. The structures of our synthesized products were confirmed by 2D-NMR experiments.First total synthesis of the proposed structures of β-indoloquinazoline alkaloids orisuaveolines A and B is re- ported. The key steps of the synthesis included a Pictet-Spengler reaction to build a six-member lactam which fur- ther transformed into target molecular by a one-pot condensation. This synthesis provided an access to the proposed structures of orisuaveolines A and B in a short and convenient manner from inexpensive, commercially available starting materials. The structures of our synthesized products were confirmed by 2D-NMR experiments.

关 键 词：orisuaveolines A and B indoloquinazoline alkaloids Pictet-Spengler reaction one-pot condensation 

分 类 号：O629.9[理学—有机化学] O413[理学—化学]