Stereoselective Synthesis of （-）-Chloramphenicol, （＋）-Thiamphenicol and （＋）-Sphinganine via Chiral Tricyclic Iminolactone  

作　　者：Qiong Li Hongbo Zhang Chenguang Li Pengfei Xu 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China [2]College of Pharmacy, Lanzhou University, Lanzhou, Gansu 730000, China

出　　处：《Chinese Journal of Chemistry》2013年第1期149-153,共5页中国化学（英文版）

基　　金：Acknowledgement We are grateful for the National Basic Research Program of China （No. 2011CB833200）, the National Natural Science Foundation of China （Nos. 20772051, 20972058）, the ＂111＂ Program from MOE of P. R. China and the Fundamental Research Funds for the Central Universities （lzujbky-2012-90）.

摘　　要：The stereoselective syntheses of （-）-chloramphenicol, （＋）-thiamphenicol and （＋）-sphinganine are described. The two continuous chiral centers within three target molecules were constructed through aldol reaction of chiral tricyclic iminolactone and aldehyde.The stereoselective syntheses of （-）-chloramphenicol, （＋）-thiamphenicol and （＋）-sphinganine are described. The two continuous chiral centers within three target molecules were constructed through aldol reaction of chiral tricyclic iminolactone and aldehyde.

关 键 词：β-hydroxy-a-amino alcohol tricyclic iminolactone total synthesis 

分 类 号：O641.6[理学—物理化学] TQ453.4[理学—化学]