离子液体催化合成硝苯地平的研究  

Study on synthesis of nifedipine

作　　者：杨凯[1] 何敬宇[1] 段书德[1] 师维康[1] 田竞超[1] 安文墨[1] 王晓朋[1] 

机构地区：[1]石家庄学院化工学院,河北石家庄050035

出　　处：《精细与专用化学品》2013年第3期18-20,共3页Fine and Specialty Chemicals

摘　　要：以邻硝基苯甲醛、乙酰乙酸甲酯和3-氨基巴豆酸甲酯为主要原料,在无溶剂条件下,以1-丁基-3-甲基咪唑四氟硼酸盐离子液体为催化剂,合成了硝苯地平,收率可达85.7%。对产品进行了MP,IR,1HNMR和MS检测。该合成工艺具有环保、反应条件温和、操作简便、产率高和催化剂可以重复使用等优点。Nifedipine was synthesized by using o-nitrobenzaldehyde, methyl acetoacetate and 3- amino methyl crotonate as starting materials in the presence of 1-butyl-3-methylimidazolium tetrafluoroborate under sovlent free condition. The yield was 85.7%. The product was confirmed by MP, IR,1HNMR and MS. This method has many advantages, such as environmental protection, mild condition, easy operation, high yield and reusable catalyst.

关 键 词：无溶剂 1-丁基-3-甲基咪唑四氟硼酸盐 硝苯地平 

分 类 号：TQ463.5[化学工程—制药化工]