硝苯地平的微波合成研究  

Synthesis of nifedipine under microwave irradiation

作　　者：何敬宇[1] 贾鹏飞[1] 刘斯婕[1] 王晓霞[1] 师维康[1] 高翔[1] 田竞超[1] 安文墨[1] 杨凯[1] 

机构地区：[1]石家庄学院化工学院,河北石家庄050035

出　　处：《精细与专用化学品》2013年第3期21-23,共3页Fine and Specialty Chemicals

基　　金：石家庄学院博士科研启动基金和石家庄科学技术研究与发展计划项目(12120453)

摘　　要：以邻硝基苯甲醛、乙酰乙酸甲酯和3-氨基巴豆酸甲酯为主要原料,在无溶剂条件下,采用微波辐射的方式合成了硝苯地平,收率可达81.2%。对产品进行了MP,IR,1HNMR和MS检测。该合成工艺具有反应时间短、操作简便和产率高等优点。Nifedipine was obtained by using o-nitrobenzaldehyde, methyl acetoacetate and 3- amino methyl crotonate as starting materials under microwave irradiation condition without solvent. The yield was 81.2%. The product was confirmed by MP, IR, 1HNMR and MS. The advantages of the method were short reaction time, easy operation and high yield.

关 键 词：硝苯地平 微波 合成 

分 类 号：TQ463.5[化学工程—制药化工]