抗病毒抗生素17997抗单纯疱疹病毒1型豚鼠皮肤感染的疗效  

The efficacy of antiviral antibiotic 17997 on treatment of HSV-1 infected guinea pig skin infection

作　　者：陶佩珍[1] 王淑琴[1] 冷启彬[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所,北京100050

出　　处：《中华实验和临床病毒学杂志》2000年第2期125-127,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：国家自然科学基金资助!( 3 962 2 0 0 5 )

摘　　要：目的　研究 17997治疗单纯疱疹病毒 1型 (HSV 1)豚鼠皮肤感染的疗效。方法　用HSV1在豚鼠皮肤造模 ,感染后 2 4h或 48h开始局部用药 ,一日 3次 ,共 5d。同时设阿昔洛韦阳性药 ,空白霜及病毒对照。结果　 0 .3% 17997显示治疗效果 ,可减轻皮损评分 ,促进结痂 ,缩短病程。结论179970 .3%霜剂无论于感染后 2 4h或 48h开始给药 ,与病毒对照组或空白霜对照组相比均可降低病损程度 ,缩短皮损痊愈时间 ,并有统计显著性。阳性对照药 3%阿昔洛韦霜剂治疗效果较 0 .3% 17997霜剂略佳。Objective To study the treatment efficacy of antiviral antibiotic 17997 against HSV1 infected guinea pig skin infection.Methods Guinea pig skin was infected by HSV1. 24hrs or 48hrs of post infection local treatment of 0.3% 17997 cream was started, tid for five days. In the mean time, acyclovir treatment, cream treatment and virus control were included.Results Local treatment of 0.3% 17997 cream showed therapeutic effects, it reduced the average scores of skin lesion, accelerated crusting time and healing time.Conclusion 0.3% 17997 cream showed significant treatment efficacy when compared with cream and virus controls by reducing skin lesion scores and healing time. The treatment efficacy of 3.0% acyclovir cream was a little bit better than 0.3% 17997 cream.

关 键 词：单纯疱疹病毒 皮肤感染 疗效 17997抗生素 

分 类 号：R965[医药卫生—药理学]