亚洲部分地区正常人群中成人腹泻轮状病毒抗体水平调查  

Seroepidemiology of adult diarrhea rotavirus in some countries of Asia

作　　者：王长安[1] K.F.Shortridge 张宝云[1] 周伟[1] 赵贵民 屈建国[1] 赵同兴[1] 刘长青[4] 王思智[5] 朱庆义 洪涛[1] 

机构地区：[1]中国预防医学科学院病毒学研究所形态室,北京100052 [2]香港大学 [3]中国进出口商检所 [4]长春市儿童医院 [5]南京市儿童医院 [6]太原市儿童医院

出　　处：《中华实验和临床病毒学杂志》2000年第2期178-180,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的　调查亚洲部分地区正常人血清中成人腹泻轮状病毒 (ADRV)抗体水平。方法　采用特异敏感的ADRV ELISA阻断实验 ,检测长春、南京、太原、武汉、香港、尼泊尔、韩国等亚洲部分地区正常人血清中ADRV抗体。结果　 2 183例正常人血清中有 79份ADRV抗体阳性 ,阳性率为3.6 % ;在中国大陆几个地区和香港地区不同年龄组的正常人血清中 ,ADRV抗体水平较低的年龄组为 10～ 2 0和 2 0～ 30岁 ;1977年香港地区正常人群血清中测出有ADRV抗体 ,表明 1983年中国大陆发生ADRV暴发流行之前 ,香港地区曾有ADRV存在 ;观察了 1986年至 1991年 6年间香港地区正常人群人ADRV抗体水平 ,未发现有明显不同 ;在尼泊尔、韩国正常人血清中也有ADRV抗体。结论　正常人血清中ADRV抗体水平比较低 ,阳性率仅为 3.6 %。Objective Adult diarrhea rotavirus (ADRV) is the major cause of severe adult diarrhea. This paper is to survey the ADRV antibody in sera of normal persons of some areas of Asia including China cities of Changchun, Nanking, Taiyuan, Wuhan, Kathmandu of Nepal, Seoul of South Korea and Hong Kong China.Method The ADRV antibody was detected by enzyme linked immunosorbent blocking test.Results The data of survey showed that ① A total detection of 2183 normal sera from persons of Asian areas showed an ADRV antibody positive rate of 3.6%(79/2183);② In cities of China and in Hong Kong, the ADRV antibody showed a lowerlevel in age groups of 10 20,20 30 ;③ The ADRV antibody was detectabe in normal persons in 1997 in Hong Kong which indicated an earlier existence of ADRV there before the ADKV outbreak in China's Mainland in 1983;④ The ADRV antibody level observed in 1986 1991 in Hong Kong showed no obvious difference;⑤ ADRV antibody was detectable in normal persons in Nepal and South Korea.Conclusion The survey showed there was only a low level of ADRV antibody in normal persons in the Asian areas surveyed.

关 键 词：腹泻 成年人 轮状病毒 ELISA 流行病学 

分 类 号：R446.62[医药卫生—诊断学]