CRUSADE评分指导非ST段抬高心肌梗死患者围手术期抗栓治疗  

Perioperative antithrombotic therapy in patients with NSTEMI under guidance of CRUSADE bleeding score

作　　者：周可[1] 侯磊[1] 肖丹[1] 张戟[1] 沈建颖[1] 徐亚伟[1] 

机构地区：[1]同济大学附属第十人民医院心内科,上海200072

出　　处：《同济大学学报（医学版）》2013年第1期91-95,共5页Journal of Tongji University(Medical Science)

摘　　要：目的探讨CRUSADE出血评分指导高出血风险的非ST段抬高心肌梗死(non-ST elevation acutemyocardial infarction,NSTEMI)患者的围手术期抗栓治疗。方法应用CRUSADE出血评分对接受再灌注治疗的NSTEMI患者进行出血危险分层,分为低出血风险组(CRUSADE出血评分1～30分)及高出血风险组(CRUSADE出血评分41～91分),共120例,两组患者采取不同的围手术期抗栓治疗方案,观察住院期间、30 d的出血事件及主要心血管事件。结果据CRUSADE出血评分,在NSTEMI围手术期高出血风险组与低出血风险组采取不同的抗栓治疗方案,住院期间、30 d两组出血事件差异无统计学意义,主要心血管事件无显著差异无统计学意义。结论 CRUSADE出血评分有助于优化NSTEMI高危出血患者围手术期的抗栓治疗。Objective To assess the perioperative antithrombotic therapy in patients with non-ST segment elevation myocardial infarction （NSTEMI） at high bleeding risk under the guidance of CRUSADE bleeding score. Methods CRUSADE bleeding score was applied in 120 NSTEMI patients undergoing reperfusion therapy for risk stratification. The patients in low CRUSADE group （1 - 30） and the patients in high CRUSADE group （41 -91 ） were treated with different protocols, bleeding events and major cardiovascular events were observed during 30 days. Results According to CRUSADE bleeding score, NSTEMI patients with high bleeding risk and low bleeding risk groups took different antithrombotic therapy during perioperative period, two groups have no significant difference in bleeding events and major cardiovascular events during 30 days. Conclusion The CRUSADE bleeding score may optimize perioperative anticoagulation therapy in patients with NSTEMI at high risk of bleeding.

关 键 词：冠状动脉疾病 CRUSADE评分 出血 预后 

分 类 号：R542.22[医药卫生—心血管疾病]