早期帕金森病中多巴胺转运体的显像及其与D_2受体显像比较  

Dopamine Transporter Imaging in Early Parkinson's Disease, Comparing with Imaging of D_2 Receptor

作　　者：李培勇[1] 陈刚[1] EvelineD 

机构地区：[1]上海第二医科大学附属瑞金医院核医学科,上海市200025 [2]DepartmentofNuclearMedicine,UniversityHospitalofInnsbruck

出　　处：《中国医学影像学杂志》2000年第4期287-289,共3页Chinese Journal of Medical Imaging

摘　　要：目的 :了解早期帕金森病患者大脑内多巴胺转运体及多巴胺D2 受体的变化情况。材料和方法 :7例早期帕金森病患者和 7例正常人进行大脑12 3 I β CIT/SPECT显像 ;其中 5例进行12 3 I β IBZM /SPECT显像。计算纹状体与小脑的放射性比值 ,分析双侧纹状体中 β CIT和IBZM的特异性摄取。 结果 :7例患者症状对侧和症状同侧纹状体 18小时的 β CIT特异性摄取指数为 2 .3± 0 .4和 4.1± 0 .3 ,纹状体的非对称指数为 2 3 .3± 6.8;其中 5例患者症状对侧和症状同侧纹状体的12 3 I IBZM特异性摄取指数分别为 1.8± 0 .2和 1.7± 0 .2 ,非对称指数为 2 .0± 0 .1。结论 :早期帕金森病患者双侧纹状体中多巴胺转运体的丢失比D2 受体的变化更早 ,更明显。Purpose:To evaluate the changes of dopamine transporter and D 2 receptor in early Parkinson's disease. Materials and Methods:Seven patients with Parkinson's disease and seven normal subjects underwent 123 I beta CIT/SPECT. Among the patients, 5 had 123 I IBZM/SPECT. Specific uptake of 123 I beta CIT and 123 I IBZM were expressed as the ratio of radioactivity between striatum and cerebellum. Results:20 hours after injection, the specific uptake of 123 I beta CIT in striatum contralateral and ipsilateral to the side of symptom was 2.3±0.4 and 4.1±0.3, respectively; asymmetrical index was 23.3±6.8. The specific uptake of 123 I IBZM in striatum was 1.8±0.2 and 1.7±0.2, respectively; asymmetrical index was 2.0±0.1. Conclusion:The loss of bilateral dopamine transporter in early Parkinson's disease is earlier and more obvious than the changes of D 2 receptor.

关 键 词：帕金森病 多巴胺转运体 多巴胺D2受体 Β-CIT 

分 类 号：R817.41[医药卫生—影像医学与核医学] R742.504[医药卫生—放射医学]