酒石酸布托啡诺对全麻诱导期枸橼酸芬太尼诱发呛咳的影响  

Effects of Butorphanol Pretreatment on Fentanyl-induced Cough during General Aneasthesia Induction

作　　者：万路[1] 贾佳[1] 刘瑶[1] 黄宁[1] 王国年[1] 

机构地区：[1]哈尔滨医科大学附属第三医院麻醉科,黑龙江哈尔滨150081

出　　处：《现代生物医学进展》2013年第1期119-121,106,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨布托啡诺对全麻诱导期芬太尼诱发呛咳的影响。方法:将80例ASAⅠ-Ⅱ级患者随机分成两组,布托啡诺组和对照组(每组40例)。麻醉诱导前预注布托啡诺(布托啡诺组)或等量生理盐水(对照组),5 min后由外周静脉快速注射芬太尼3μg/kg(2 s内),观察2 min内呛咳反应的发生率,随后给予依托咪酯0.3 mg/kg,顺式阿曲库铵0.15 mg/kg进行气管插管,行机械通气并观测血流动力学变化。结果:布托啡诺组仅有2例患者出现轻中度呛咳(5%),而对照组有27例(67.5%)出现不同程度的呛咳,其中轻度8例(20.0%),中度15例(37.5%),重度为4例(10.0%)。与对照组相比,布托啡诺组血流动力学更为平稳。结论:全麻诱导前5 min预注射布托啡诺可显著抑制芬太尼诱发的呛咳反应,且可减轻插管反应。Objective： To investigate the effects of pre-induction butorphanol administration on fentanyl-induced cough during aneasthesia induction. Methods： 80 elective surgical patients, scaled I - II by ASA, were randomly divided into two groups. Butor- phanol or equal Volume normal saline was injected through peripheral cannula 5 minutes prior to intravenous administration of 3 μg/kg fentanyl in 2 seconds. The incidence of cough was observed in 2 minutes and hemodynarnics during the procedure were recorded. Results： Only 2 （5 %） patients had mild to moderate cough in pre-treatrnent butorphanol group, while 27 （67.5 %） patients in control group, in which there were 8 mild cases （20.0 %）, 15 moderate （37.5 %） and 4 severe （10.0 %）. Besides, compared with control group, the blood- pressure and heartrate of patients in pre-treatrnent butorphanol group were more stable. Conclusions： Butorphanol pre-treatment 5 min before induction significantly suppresses fentanyl-induced cough and intubation reaction during general aneasthesia induction.

关 键 词：布托啡诺 芬太尼 呛咳反应 

分 类 号：R614[医药卫生—麻醉学]