肺炎链球菌粘附和毒力因子A研究进展  

Progress in Pneumococcal Adherence and Virulence Factor A

作　　者：郭旭光[1] 冀天星[2] 夏勇[1] 

机构地区：[1]广州医学院第三附属医院检验科,广东广州510150 [2]广州医学院第二附属医院检验科,广东广州510260

出　　处：《现代生物医学进展》2013年第1期197-200,共4页Progress in Modern Biomedicine

基　　金：广州医学院青年基金项目(2010A26);广州市医药卫生科技一般引导项目(20121A011160);广州市中医药和中西医结合科研项目(20122A011033)

摘　　要：肺炎链球菌(Streptococcus pneumoniae,SP)普遍定植于呼吸道,是人类重要的侵袭性病原菌之一,是社区获得性肺炎、中耳炎、脑膜炎、菌血症、鼻窦炎的主要病原菌。肺炎链球菌粘附和毒力因子A(pneumococcal adherence and virulence factor A,PavA)是肺炎链球菌早期感染和侵袭过程中关键的毒力因子。体外试验表明,缺失PavA的肺炎链球菌的突变株其粘附和侵入上皮细胞和内皮细胞的能力明显下降。作为一种保护性抗原,其诱导的细胞和体液免疫可以有效的抵抗肺炎链球菌的感染,是肺炎链球菌新一代疫苗的候选蛋白。但是,PavA在肺炎链球菌与人肺上皮细胞交互对话中作用机制的研究尚属空白,本文就肺炎链球菌粘附和毒力因子A得最新研究进展作一综述。Streptococcus pneumoniae is a natural resident of the upper and lower respiratory tracts of humans, as well as the major cause of community acquired pneumonia and bacterial meningitis, has been shown to transiently invade epithelial and endothelial cells. Pneumococcal adherence and virulence factor A （PavA） is displayed to the cell outer surface of Streptococcus pneumoniae and mediates pneumococcal binding to epithelial cell lines.PavA, which lacks a typical gram-positive signal sequence and cell surface anchorage motif, is essential for pneumococcal virulence. However, the mechanism of PavA in the interactive dialogue in the Streptococcus pneumoniae with human lung epithelial cells is still unknown.

关 键 词：肺炎链球菌 链球菌 毒力因子 肺泡上皮细胞 PavA 

分 类 号：R378.14[医药卫生—病原生物学]