右美托咪定在小儿气管异物取出术中的应用  

The Application of Dexmedetomidine in Pediatric Tracheobronchial Foreign Body Removal Surgery

作　　者：赵东波[1] 张沛重[1] 李征[2] 贾佳[3] 黄宁[3] 

机构地区：[1]南阳医学高等专科学校附属第一医院麻醉科,河南南阳473000 [2]哈尔滨医科大学附属第一医院麻醉科,黑龙江哈尔滨150001 [3]哈尔滨医科大学附属第三医院麻醉科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2013年第2期275-277,326,共4页Progress in Modern Biomedicine

摘　　要：目的:观察右美托咪定在气管异物取出术中对患儿呼吸、循环及术后恢复情况的影响。方法:40例行气管异物取出术患,随机分为右美托咪定组(D组)(n=20)和生理盐水组(S组)(n=20),分别在麻醉诱导前10min静脉输注右美托咪定0.8μg/kg和等容量的生理盐水,输注时间为10min。术中高频射流呼吸机给氧,保持患儿自主呼吸,泵注丙泊酚和瑞芬太尼维持麻醉。结果:D组患儿术中屏气、咳嗽、喉痉挛、术中SP02<90%显著低于S组(P<0.05);D组丙泊酚及瑞芬太尼用量减少(P<0.05)。结论:在气管异物取出术中应用右美托咪定有很大的优势,对呼吸系统影响小,血流动力学平稳,术后并发症少。Objective： To observe the effects of respiration, cardiovascular response and postoperative recovery using Dexmedetomidine in pediatric tracheobronchial foreign body removal surgery. Methods： Fourty patients scheduled for intraeranial aneurysm were divided randomly into two groups （n=20 each）： 0.9 saline group （group S）; dexmedetomidine group（group D）. In group D, 10 min before anesthesia induction, dexmedetomidine 0.8μg/kg was infused over 10 min, while saline group was given equal volume of normal saline instead of dexmedetomidine in group S. In surgery, Oxygen was supplied by high-frequency jet ventilator, anesthesia was maintained by infusion ofpropofol and remifentanil,patients maintained spontaneous breathing. Results： Compared with S Group breath, coughing, laryngospasm and SP02 〈 90% were significantly decreased （P〈0.05）. Group D given propofol and remifentanil dosage was significantly less than the group S （P〈0.05）. Conclusion： The application of Dexmedetomidine has a great advantage in pediatric tracheobronchial foreign body removal surgery .It makes hemodynamic parameters more stable and fewer postoperative complications, especially has the lighter effects on the respiratory system.

关 键 词：右美托咪定 气管异物 高频喷射通气 自主呼吸 

分 类 号：R614[医药卫生—麻醉学]