长效化Exendin-4的研究进展  

Research Progress of Long-acting Exendin-4

作　　者：章成昌[1] 陈建华[1] 

机构地区：[1]中国药科大学生命科学学院,江苏南京210009

出　　处：《现代生物医学进展》2013年第2期371-374,378,共5页Progress in Modern Biomedicine

摘　　要：Exendin-4是一种新型GLP-1类似物,已被用于2型糖尿病的治疗。由于其优良的药学特性成为糖尿病治疗的亮点,而进一步开发设计长效Exendin-4药物成为近年2型糖尿病药物研究的热点。本文就长效Exendin-4药物的国内外研究进展、作用机制以及药效学性质做一综述。Exendin-4 is a novel Glucagons-like peptide 1 （GLP-1） analogs,which has been used for type 2 diabetes due to its excellent pharmaceutical features. In recent years, the long-acting Exendin-4 has been further developed, which has become the hot spot of type 2 diabetes drug research. This article reviews the domestic and foreign research progress, mechanism of action, and pharmacodynamic properties of long-acting Exendin-4.

关 键 词：EXENDIN-4 2型糖尿病 长效 

分 类 号：R587.1[医药卫生—内分泌] R96[医药卫生—内科学]