绍兴市区中老年呼吸道过敏性疾病血清吸入性变应原检测结果分析  

DETECTION AND ANALYSIS OF INHALED ALLERGENS IN SERUM OF THE ELDERLY PEOPLE WITH RESPIRATORY ALLERGIC DISEASES IN SHAOXING CITY

作　　者：倪铁钧[1,2] 杨明峰[1,2] 冯一[1,2] 叶雅萍 

机构地区：[1]浙江省绍兴市人民医院 [2]浙江大学绍兴医院分子医学中心,浙江绍兴312000 [3]温州医学院仁济学院,生物科技专业浙江温州325000

出　　处：《河北医科大学学报》2013年第2期181-183,共3页Journal of Hebei Medical University

摘　　要：目的了解绍兴市区中老年呼吸道过敏性疾病血清中吸入性变应原季节分布特征,为预防和治疗提供科学依据。方法选择2010年12月—2011年11月在绍兴市人民医院呼吸科住院治疗的确诊为呼吸道过敏性疾病的中老年患者176例,采用德国敏筛变应原检测系统以免疫印迹法定量检测血清中9项吸入性变应原特异性IgE抗体浓度以及总特异性IgE抗体浓度。结果中老年呼吸道过敏性疾病患者9项吸入性变应原特异性IgE抗体阳性表达在春秋两季以Mx1菌霉素、D1户尘螨为主,夏季以Mx1菌霉素、W1矮豚草为主,冬季以Tx4梧桐杨树等为主(阳性率>15%);春、夏季中老年呼吸道过敏性疾病患者变应原总特异性IgE抗体阳性率明显高于秋、冬季(P<0.05)。结论中老年呼吸道过敏性疾病患者应根据变应原季节分布特征加强预防,在空气污染严重的季节最好到低污染的山区生活,以降低发病率。Objective To understand the season characteristics of inhaled allergen distribution in the elderly people with respiratory allergic diseases in Shaoxing city, and provide a scientific basis for the prevention and treatment. Methods A total of 176 cases of elderly patients were chosen,who were diagnosed with allergic respiratory disease in department of respiration of Shaoxing People~ Hospital from December 2010 to November 2011. The specific IgE antibody of nine inhaled allergens and the total specific IgE antibody were quantitated by immunoblot method using Mediwiss allergen detection system. Results In spring and autumn, the main inhaled allergens were Mxl Mycomycin, D1 Household dust mites, and in summer they were Mxl, W1 short ragweed, however in winter they were Tx4 phoenix tree, poplar etc （rate of positive 〉 15% ）. The positive rate of the total specific IgE antibody of patientswith respiratory allergic diseases in spring and summer was significantly higher than in autumn and winter（P 〈 0.05）. Conclusion The elderly patients with respiratory allergic diseases should be enhanced more prevention based on the seasonal distribution characteristics of allergen. In order to reduce the risk of disease, they can live far away from the city in the season with serious air pollution.

关 键 词：呼吸道疾病 过敏反应 变应原 

分 类 号：R593.1[医药卫生—内科学]