幼年特发性关节炎49例临床分析  

JUVENILE IDIOPATHIC ARTHRITIS: CLINICAL ANALYSIS OF 49 CASES

作　　者：程娜[1] 常红[1] 张秋业[1] 甄红花 庄超 张守青[1] 孙燕[1] 

机构地区：[1]青岛大学医学院附属医院儿内科,山东青岛266003 [2]山东省章丘市人民医院 [3]青岛市儿童医院

出　　处：《青岛大学医学院学报》2013年第1期73-75,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨幼年特发性关节炎(JIA)的临床特点及治疗方案。方法对2007年1月—2012年5月本院收治的49例JIA病儿的临床资料进行回顾性分析。结果 49例中全身型32例;多关节类6例,其中类风湿因子阳性2例,阴性4例;少关节类7例;与附着点炎症相关性关节炎(ERA)4例。35例采用非甾体类抗炎药(NSAID)或NSAID联合糖皮质激素治疗(全身型23例,多关节炎型4例,少关节炎型6例,ERA者2例);全身型中4例加用甲氨蝶呤(MTX)或羟氯喹治疗,5例给予甲强龙冲击治疗;2例多关节炎型加用了免疫抑制剂;1例少关节炎型给予甲泼尼龙琥珀酸钠冲击治疗;2例ERA应用了MTX治疗。结论 JIA诊断主要依靠临床特征,强调除外其他系统疾病。JIA临床表现多样,应根据不同个体的疾病活动情况给予个体化治疗方案。Objective To explore the clinical characteristic of juvenile idiopathic arthritis （JIA） and its treatment proto- cols. Methods Clinical data of 49 patients with JlA-treated during Jan 2007-- May 2012- were retrospectively analyzed. Re- suits Of the 49 cases reviewed,32 with systemic arthritis, six with polyarthritis （including two with positive rheumatoid factor and four with negative rheumatoid factor）, seven with oligoarthritis, and four with enthesitis-related arthritis （ERA）. Thirty-five patients were treated with either non-steroidal anti-inflammatory drugs （NSAID） or NSAID combining with glucocorticoid （23 with systemic arthritis, four with polyarthritis, six with oligoarthritis and two with ERA）. In systemic arthritis, methotrexate （MTX） or hydroxychloroquine was added to four patients, and glucocorticoid stosstherapy to five patients. Two patients with polyarthritis received additional immunosuppressive agents, one with oligoarthritis received glucocorticoid stosstherapy; two with ERA were given MTX. Conclusion The diagnosis of JIA mainly depends on the clinical features, excluding other diseases should be em- phasized. The clinical manifestations of JIA are varied. Individualized therapeutic schedule should be given based on different indi- viduals.

关 键 词：幼年特发性关节炎 诊断 治疗结果 

分 类 号：R725.9[医药卫生—儿科]