持续不卧床腹膜透析患者血清缺血修饰白蛋白水平变化  

The change of serum ischemia modified albumin level in continuous ambulatory peritoneal dialysis patients

作　　者：苏晓燕[1] 郑伟平[1] 关晓东[1] 邹朝晖[1] 陈丽[1] 

机构地区：[1]中山大学附属东华医院肾内科,广东东莞523110

出　　处：《中国医师进修杂志》2013年第6期3-5,共3页Chinese Journal of Postgraduates of Medicine

基　　金：广东省东莞市科技计划医疗卫生类科研一般项目（201210515000387）

摘　　要：目的观察持续不卧床腹膜透析（CAPD）患者血清缺血修饰白蛋白（IMA）水平的变化。方法74例接受CAPD大于3个月的慢性肾脏病5期患者（CAPD组），根据有无不同程度心血管疾病临床症状分为CAPD有症状组（29例）和CAPD无症状组（45例），并选择70例健康体检者作为对照组。观察并比较各组血清IMA水平、心电图及心脏彩超异常发生情况。结果CAPD组血清IMA水平为（92．33±17．17）kU/L，明显高于对照组的（69．63±9．24）kU/L，差异有统计学意义（P〈0．01）。CAPD有症状组血清IMA水平为（109．37±21．34）kU/L，明显高于CAPD无症状组的（85．31±8．58）kU/L，差异有统计学意义（P〈0．05）。CAPD有症状组血清IMA水平升高率、心电图及心脏彩超异常发生率分别为37．9％（11，29）、62．1％（18/29），明显高于CAPD无症状组的15．6％（7/45）、22．2％（10／45）。差异有统计学意义（P〈0．05）。结论CAPD患者血清IMA水平升高，CAPD有心血管疾病临床症状的患者血清IMA水平明显升高，IMA可作为诊断CAPD患者心肌损害的指标。Objective To observe the change of serum ischemia modified albumin （IMA） in continuous ambulatory peritoneal dialysis （CAPD） patients. Methods Seventy-four end stage renal disease patients undergoing CAPD more than 3 months （CAPD group） were divided into 2 groups according to clinical symptoms of cardiovascular diseases：CAPD symptoms group （29 cases） and CAPD asymptomatic group （45 cases）. Seventy healthy subjects were selected as control group. The serum IMA level and abnormal rate of electrocardiogram and heart color ultrasonic were examined and compared. Results The serum IMA level in CAPD group was significantly higher than that in control group [ （92.33 ± 17.17） kU/L vs. （69.63 ± 9.24）kU/L,P 〈 0.01 ]. The serum IMA level in CAPD symptoms group was significantly higher than that in CAPD asymptomatic group [ （ 109.37 ±21.34） kU/L vs. （85.31 ± 8.58 ） kU/L, P 〈 0.05 ]. The elevatory rate of serum IMA level and abnormal rate of electrocardiogram and heart color ultrasonic in CAPD symptoms group were significantly higher than those in CAPD asymptomatic group [37.9%（11/29） vs. 15.6% （7/45）,62.1% （18/29） vs. 22.2% （10/45）,P 〈0.05]. Conclusions The serum IMA level in CAPD patients is elevatory. Serum IMA level is significantly higher in CAPD patients with cardiovascular disease clinical symptoms, it can be used for diagnosis of myocardial damage in CAPD patients.

关 键 词：肾功能衰竭 慢性 腹膜透析 持续不卧床 缺血修饰白蛋白 

分 类 号：R692[医药卫生—泌尿科学]