靶向性Fe_3O_4@Au纳米粒子在光声/核磁双模成像中的应用  

Targeted Fe_3O_4@Au nanoparticle as a dual-modality probe for MRI and PAI

作　　者：覃欢[1] 周婷[1] 杨思华[1] 邢达[1] 

机构地区：[1]华南师范大学生物光子学研究院激光生命科学研究所,激光生命科学教育部重点实验室,广州510631

出　　处：《科学通报》2013年第7期580-585,共6页Chinese Science Bulletin

基　　金：国家重点基础研究发展计划(2011CB910402;2010CB732602);长江学者和创新团队发展计划创新团队项目(IRT0829);国家自然科学基金(81127004;11104087);华南师范大学研究生科研创新基金(2012kyjj122;2012kyjj117)资助

摘　　要：多模互补成像可以提高医学诊断精度.多模探针是联合各个成像模式的桥梁,这意味着发展多模式、多功能的纳米探针是非常必要的.本文发展了一种具有靶向性的四氧化三铁核/金壳纳米粒子(Fe3O4@Au)作为核磁和光声双模成像的探针,实验证明Fe3O4@Au纳米粒子具有超顺磁性,可以增强T2序列的核磁信号.此外,该探针同时具有光学吸收性质,可以增强光声信号.在其表面修饰Integrin?v?3单克隆抗体后,该探针对U87-MG肿瘤细胞具有选择靶向性.基于Fe3O4@Au纳米粒子的核磁/光声双模成像将在肿瘤诊断中发挥重大作用.Multimodality imaging promises to improve the accuracy of medical diagnosis. The multi-modality probes can combine every single imaging modality together. This led to the emergence of the multimodal contrast agents which can generate contrast in different modalities, simultaneously. In this work, we developed the bio-modified Fe3O4 core/Au shell nanoparticles （Fe3O4@Au NPs） as a dual-modality probe for magnetic resonance imaging （MRI） and photoacoustic imaging （PAl）. Fe304@Au NPs integrated magnetization and light absorption properties could be utilized for MRI and PAl dual-modality detection of cancer cell. When conjugated with a cancer cell targeted molecule, Fe3O4@Au NPs could be internalized by the corresponding cancer cells selectively and sensitively. With Fe3O4@Au NPs, the combination of MRI and PAI will provide an important new application in medical diagnosis of cancer.

关 键 词：光声成像 核磁成像 双模成像 纳米粒子 

分 类 号：TB383.1[一般工业技术—材料科学与工程]