节段型与非节段型白癜风临床特征比较及治疗现状初步调查  

Clinical analysis and treatment of 1025 patients with segmental and non-segmental vitiligo:a preliminary survey

作　　者：叶莹[1] 周莲宝[1] 项蕾红[2] 

机构地区：[1]复旦大学附属儿科医院皮肤科,上海201102 [2]复旦大学附属华山医院皮肤科,上海200040

出　　处：《临床皮肤科杂志》2013年第3期142-144,共3页Journal of Clinical Dermatology

摘　　要：目的:了解白癜风不同临床类型的相关特征和常用治疗方法的临床应用情况。方法:采用问卷调查方法,收集临床资料,输入EPIDATA 3.1数据库,应用STATA软件对数据进行统计学分析。结果:调查的1025例白癜风患者中,男女比例为0.83:1,临床类型中节段型占19.0%,非节段型占81.0%;局限型占总人数的18.3%,散发型占56.4%,肢端型占5.3%,而泛发型只占1%。平均发病年龄(23.2±12.5)岁,主要集中在11～20岁(40.2%),疾病平均病程为38个月(中位数),复发率为6.7%。同形反应、伴有晕痣各占16.9%和7.8%,且非节段型患者发生的概率皆高于节段型患者。通过比较各种治疗方法,光疗及自体表皮移植的治疗有效率较高,分别为80.3%和92.7%,但临床应用率较低,仅为16.6%和20.5%。结论:白癜风病程长,复发率低,非节段型患者出现同形反应、晕痣的比率高于节段型。临床上应大力推广光疗,对于稳定期的患者,可行自体表皮移植治疗。Objective： To study the clinical features and treatment of vitiligo through a large-population epidemiological survey. Methods： A questionnaire survey was carried out to collect clinical data from 1 025 cases of vitiligo. EpiData and STATA were utilized for statistical analysis. Results： In 1 025 patients with vitiligo, the ratio of male to female was 0.83 to 1. The mean age at onset was （23.2±12.5） years, mainly concentrated in the 11 to 20 years （40.2%）. The mean duration of disease was 38 months. The most common type was non-segmental vitiligo （81%）, while segmental type accounted for 19% of the 1 025 patients. Focal, generalized, acral, and universal type accounted for 18.3%, 56.4%, 5.3% and 1%, respectively. The relapse rate was 6.7%. The incidences of Koebner＇s phenomenon and halo nevus in the vitiliginous areas were 16.9% and 7.8%. The prob- abilities of these clinical features in the patients of non-segmental were both higher than those of the patients of segmental vi- tiligo（P 〈 0.05）. Among several therapies, the response rates of phototherapy and autologous epidermal grafting were higher than other therapies, they were 80.3% and 92.7%, respectively, but they were less used currently. Conclusions： itiligo is a disease of chronic course and low incidence of relapse. The incidences of Koebner＇s phenomenon, halo nevus and white hairs in the vitiliginous areas of non-segmental vitiligo were higher than those of segmental vitiligo. It is the author＇s opinion that pho- totherapy should be popularized in the clinics and autologous epidermal grafting can be used for patients in stable stage.

关 键 词：白癜风 流行病学 治疗 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]