新生儿侵袭性真菌感染24例临床分析  

Clinical analysis of invasive fungal infection in 24 cases of newborn infants

作　　者：郭静[1] 金娟[1] 康文清[1] 

机构地区：[1]郑州市儿童医院新生儿重症监护室,450053

出　　处：《中国实用医刊》2013年第6期29-30,共2页Chinese Journal of Practical Medicine

摘　　要：目的分析新生儿侵袭性真菌感染的临床特点、易感因素、治疗及预后。方法对2010年1月至2011年12月郑州市儿童医院收治的新生儿中24例发生侵袭性真菌感染的患儿资料进行回顾性总结。结果新生儿侵袭性真菌感染发病高危因素为早产、低出生体质量儿、机械通气、留置导管、长期使用抗生素、住院时间长。常见的临床症状为发热、反应差、呼吸增快或呼吸暂停增加、腹胀、胃锄道不耐受、血小板减少。致病菌中以白色念珠茵为主，早期应用氟康唑效果好。结论新生儿侵袭性真菌感染临床表现不典型，氟康唑治疗有效，早期治疗预后好。Objective To analyze the clinical features, risk factors, treatment and prognosis of invasive fungal infection. Methods The clinical data of 24 infants with invasive fungal infection during January 2010 and December 2011 from Zhengzhou children＇s hospital were retrospectively concluded. Results The high risk factors of invasive fungal infection in newborn infants include preterm, low birthweight, mechanical ventilation, inserting catheter, broad-spectrum antibiotic. The common clinical presentations were fever, lethargy, tachypnea or apnea more than before, abdominal distension, feeding intolerance and thrombocytopenia. The candia albicans was the major pathogen. Early-started the treatment of fluconazole can improved the prognosis. Conclusions The clinical presentations of invasive fungal infection are always nonspecific. Flucon- azole appears to be effective. Early-started antifungal therapy can improve the prognosis.

关 键 词：新生儿 侵袭性真菌感染 易感因素 

分 类 号：R519[医药卫生—内科学]