儿童急性淋巴细胞白血病预防性血小板输注阈值探讨  

The threshold analysis for prophylactic platelet transfusions in childhood acute lymphoblastic leukemia

作　　者：周令[1] 徐学聚[1] 李欢欢[1] 

机构地区：[1]郑州大学第一附属医院儿科,450052

出　　处：《中国实用医刊》2013年第6期38-40,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨急性淋巴细胞性白血病患儿化疗过程中预防性血小板输注阈值。方法分析郑州大学第一附属医院儿科2年间急性淋巴细胞白血病惠儿化疗期间血小板输注及出血情况。结果110例患儿共输注血小板385例次，无合并症组血小板计数〈5×10^9／L时输注血小板，临床主要出血事件增加，有合并症组在血小板计数〈10×10^9／L时临床出血风险增加。结论儿童急性淋巴细胞白血病化疗过程中，在患儿一般状态稳定情况下．血小板输注阈值定为5x10’／L相对安全，有合并症时血小板输注阈值应为10×10^9／L或更高。Objective To investigate the threshold for prophylactic platelet transfusions in childhood acute lymphoblastic leukemia（ALL）. Methods To analyze platelet transfusions and bleeding condition during chemotherapy in our department in childhood with ALL. Results 110 cases of children with a total 385 cases platelet transfusions. No complication group platelet count 〈 5 × 10^9/L, given platelet transfusion, major clinical bleeding events increased, complication group platelet count 〈 5 × 10^9/L, the risk of clinical bleeding increased. Conclusions The platelet transfusions threshold of 5 × 10^9/L for stable ALL patients is safe during chemotherapy. The platelet transfusion trigger was increased to 10 × 10^9/L or even higher in certain clinical situations.

关 键 词：血小板输注 阈值 急性淋巴细胞白血病 儿童 

分 类 号：R457.1[医药卫生—治疗学]