嗜酸性筋膜炎16例报道和文献回顾  

Report of 16 cases of eosinophilic fasciitis with literature review

作　　者：王慧[1] 吴爱瑜[1] 段新旺[1] 曾小峰[1] 王迁[1] 

机构地区：[1]中国医学科学院北京协和医院风湿免疫科,100032

出　　处：《中华风湿病学杂志》2013年第3期179-181,共3页Chinese Journal of Rheumatology

摘　　要：目的总结嗜酸性筋膜炎（EF）病例并复习相关文献，以提高对该病认识。方法对北京协和医院1990年1月至2011年12月收治的16例住院患者的人口学特点、临床表现、系统受累、实验室检查、病理及治疗等进行分析。结果①16例患者中男性13例，女性3例；平均发病年龄（47±8）岁；②3例在发病前有明确的劳累或剧烈运动史；③6例存在抗核抗体阳性（6／12）；3例类风湿因子（RF）阳性（3／10）；6例出现高1球蛋白血症（6／7）；8例IgG增高（8／13）；10例出现嗜酸性粒细胞增高（10／16）；④仅1例出现血小板减低（1／16），余无系统受累表现。结论本病可能为遗传因素和环境因素共同参与发病的一种自身免疫病。系统受累较少。激素及免疫抑制剂对本病有效。Objective We reported 16 eosinophilie fasciitis （EF） patients with eosinophilic fasciitis and performed a systematic review of the literature to improve the disease awareness. Methods The clinical course of 16 patients with eosinophilie fasciitis at the Peking Union Medical College Hospital were described, inclu-ding demographic data, clinical manifest-ations, laboratory tests, pathology and treatment. Results The mean age at diagnosis was （47±8） years, with 13 female and 3 male patients. Three cases had exertion or strenuous sports before the onset of EF. Positive ANA was noted in 6 of 12, positive RF was noted in 3 of 10, hyper-gammaglobulinemia was noted in 6 of 7, elevated IgG was noted in 8 of 13, peripheral blood eosinophilia was noted in 10 of 16, while thromboeytopenia was found in one patient. Conclusion Based on this and other reported cases in the literature, EF may be a kind of autoimmune disease. Genetic influence and environ-mental factors are involved in the development of this disease. Systemic involvement is rare. In general, corticosteroids and immunosuppressive are effective in EF.

关 键 词：自身免疫疾病 回顾性研究 嗜酸性筋膜炎 

分 类 号：R593.2[医药卫生—内科学]