脑动静脉畸形γ刀放射治疗后脑水肿发生情况分析  被引量:1

Incidence of cerebral edema in patients with cerebral arteriovenous malformations treated by radiosurgery

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作  者:利唏[1] 梁舜尧[2] 谭理连[1] 胡滨[3] 侯仲军[1] 陈耀棠[1] 于晓君[1] 曹兵艺[1] 

机构地区:[1]广州医学院第二附属医院放射科,广州510260 [2]广州医学院第二附属医院放射治疗科,广州510260 [3]广州医学院第二附属医院神经外科,广州510260

出  处:《中华神经医学杂志》2013年第3期305-307,共3页Chinese Journal of Neuromedicine

摘  要:目的探讨脑动静脉畸形γ刀放射治疗后不同随访阶段放射性脑水肿的发生率。方法回顾性分析广州医学院第二附属医院放射科自1995年1月至2010年12月十余年间内经γ刀治疗的脑动静脉畸形患者的临床资料,共经磁共振检查随访351例次。统计叮刀术后不同随访阶段放射性脑水肿发生率并采用采用r检验分析。结果1刀放射治疗后本组患者放射性脑水肿阳性率为36.2%;不同随访阶段放射性脑水肿阳性率分别为:≤12月43.0%,13~36月45.3%,37~60月23.1%,61~120月13.6%,〉120月5.9%;各随访阶段间放射性脑水肿的发生率比较差异有统计学意义(X^2=26.514,P=0.000)。结论放射性脑水肿是脑动静脉畸形γ刀治疗后最常见的并发症之一,部分患者可出现顽固性放射性脑水肿。γ刀治疗后第一阶段(≤12月)、第二阶段(13~36月)放射性脑水肿发生率较高,应临床密切关注。Objective To study the incidence of cerebral edema in patients with cerebral arteriovenous malformations (AVMs) treated by Gamma knife. Methods The clinical data of 351 patients with AVMs, admitted to and treated with gamma knife in our hospital from January 1995 to December 2010, were retrospectively analyzed. MR imaging was performed on these patients to review the characteristics of cerebral edema and compare the different incidences of cerebral edema at different follow up periods; chi-square analysis was employed on these data. Results After being treated with gamma knife, the total positive rate of cerebral edema was 36.2%. At different follow-up periods, the positive rates of cerebral edema were different: 43.0% within 12 months of treatment, 45.3% at 13-36 months after treatment, 23.1% at 37-60 months after treatment, 13.6% at 61-120 months after treatment, and 5.9% more than 120 months after treatment; significant difference was noted between each two follow up periods (X^2=26.514, P=0.000). Conclusion Edema is one of the common complications after gamma knife treatment; stubborn cerebral edema might appear in some; the tiptop of cerebral edema incidence rate is at 0 to 36 months after treatment, which needs to be paid attention in clinic.

关 键 词:脑动静脉畸形 脑水肿 立体定向放射治疗 伽玛刀 并发症 

分 类 号:R543.7[医药卫生—心血管疾病]

 

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