环境内分泌干扰物壬基酚对神经系统影响的研究进展  

Review on Effects of Environmental Endocrine Disruptor Nonylphenol on Nervous System of Organisms

作　　者：俞捷[1] 张镖[1] 许洁[1] 

机构地区：[1]遵义医学院公共卫生学院,贵州遵义563003

出　　处：《环境与职业医学》2013年第3期226-228,共3页Journal of Environmental and Occupational Medicine

基　　金：贵州省科技厅自然科学基金(编号:黔科合计字2008-2190号和2011-2283号);2012遵义医学院博士启动基金(编号:F-559);贵州省2012年度大学生创新创业训练计划项目(编号:黔财教[2012]229);遵义医学院2012年度大学生创新性实验计划项目(编号:院发[2012]2901)

摘　　要：壬基酚作为一种环境内分泌干扰物,其所造成的全球生态污染受到越来越多的关注。本文以近年来国内外的毒理学研究资料为依据,综述其对神经系统的影响,认为在整体和细胞水平,壬基酚可干扰机体多巴胺和胆碱能系统,致脑组织脂质过氧化,促神经细胞凋亡,影响动物神经行为等。Nonylphenol （NP） is an environmental endocrine disruptor with estrogen-like effects, and the attentions to its global ecological pollution are increasing. The review discussed the toxic effects of NP on the nervous system of organisms with evidences provided by domestic and international toxicological studies in recent years. At the individual or cell level, NP could induce dysfunction of dopamine neurons and cholinergic systems, resulting in lipid peroxidation of cerebral tissue, apoptosis of nerve cells, as well as neurobehavioral disorders in animals.

关 键 词：壬基酚 环境内分泌干扰物 神经系统 神经递质 类固醇 生长因子 凋亡 

分 类 号：R131[医药卫生—劳动卫生]